ArticleAnnals of internal medicine2016
Warning Symptoms Are Associated With Survival From Sudden Cardiac Arrest.
Article in Annals of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Cardiac warning symptoms in paediatric out-of-hospital ventricular fibrillation cardiac arrest survivors.Open heart · 2026Article
- Clinical Triage of Individuals With Warning Symptoms of Imminent Cardiac Arrest.Circulation. Arrhythmia and electrophysiology · 2026Observational
- Incidence and clinical manifestations of sudden death in young adults: a two-decade, nationwide, retrospective, cross-sectional study.Resuscitation plus · 2026Article
- An International Physical Exercise Screening Questionnaire (IPESQ).International journal of emergency medicine · 2026Review
- First automated detection of a cardiac arrest using a commercially available smartwatch: a case report.Resuscitation plus · 2026Article
- Observational
- Patient and physician perspectives on smartwatch-based out-of-hospital cardiac arrest detection.European heart journal. Digital health · 2025Article
- Early Symptom Warnings and Long-Term Health Conditions in Childhood Cancer Survivors: Insights from the Childhood Cancer Survivor Study and St. Jude Lifetime Cohort Study.Research square · 2025Article
- [Molecular autopsy: post-mortem genetic testing following sudden cardiac death].Innere Medizin (Heidelberg, Germany) · 2025Article
- The Singapore Physical Activity Readiness Questionnaire 2021 (SPARQ 2021)-Results of Public Feedback.Healthcare (Basel, Switzerland) · 2025Article
- Near-term prediction of sustained ventricular arrhythmias applying artificial intelligence to single-lead ambulatory electrocardiogram.European heart journal · 2025Article
- Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Investigating Users' Attitudes Toward Automated Smartwatch Cardiac Arrest Detection: Cross-Sectional Survey Study.JMIR human factors · 2024Article
- Relevance of the Get Active Questionnaire for Pre-Participation Exercise Screening in the General Population in a Tropical Environment.Healthcare (Basel, Switzerland) · 2024Review
- Prevention of Sudden Cardiac Death: Beyond Automated External Defibrillators and Implantable Cardioverter Defibrillators.Circulation · 2024Article
- Pre-emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm.ESC heart failure · 2024Article
- Ventricular fibrillation and the proteome problem: can we solve it?European heart journal. Acute cardiovascular care · 2024Article
- Wolf Creek XVII part 3: Automated cardiac arrest diagnosis.Resuscitation plus · 2023Review
- Warning symptoms associated with imminent sudden cardiac arrest: a population-based case-control study with external validation.The Lancet. Digital health · 2023Article
- Heart Disease Knowledge and Awareness in African American and Hispanic Women.Southern medical journal · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- SummaryForPatientsIn
Authors and funding
11 authors.
Funding
Abstract
backgroundSurvival after sudden cardiac arrest (SCA) remains low, and tools for improved prediction of patients at long-term risk for SCA are lacking. Alternative short-term approaches aimed at preemptive risk stratification and prevention are needed.
objectiveTo assess characteristics of symptoms in the 4 weeks before SCA and whether response to these symptoms is associated with better outcomes.
designOngoing prospective population-based study.
settingNorthwestern United States (2002 to 2012). PATIENTS: Residents aged 35 to 65 years with SCA. MEASUREMENT: Assessment of symptoms in the 4 weeks preceding SCA and association with survival to hospital discharge.
resultsOf 839 patients with SCA and comprehensive assessment of symptoms (mean age, 52.6 years [SD, 8]; 75% men), 430 (51%) had warning symptoms (50% of men vs. 53% of women; P = 0.59), mainly chest pain and dyspnea. In most symptomatic patients (93%), symptoms recurred within the 24 hours preceding SCA. Only 81 patients (19%) called emergency medical services (911) to report symptoms before SCA; these persons were more likely to be patients with a history of heart disease (P < 0.001) or continuous chest pain (P < 0.001). Survival when 911 was called in response to symptoms was 32.1% (95% CI, 21.8% to 42.4%) compared with 6.0% (CI, 3.5% to 8.5%) in those who did not call (P < 0.001). LIMITATION: Potential for recall and response bias, symptom assessment not available in 24% of patients, and missing data for some patients and SCA characteristics.
conclusionWarning symptoms frequently occur before SCA, but most are ignored. Emergent medical care was associated with survival in patients with symptoms, so new approaches are needed for short-term prevention of SCA. PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.