ArticleInvestigative ophthalmology & visual science2015
Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of Insulin Resistance on Retinal Ganglion Cell Layer Structures: Findings from the Korea National Health and Nutrition Examination Survey.Journal of clinical medicine · 2026Article
- Inner retinal structure and intraocular pressure in children with obesity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- iPSC-derived ITGA6-positive cells restore aqueous humor outflow in glaucoma eyes.Nature communications · 2025Article
- Association Between Intraocular Pressure and Risk Factors for Metabolic Syndrome in Korea.Journal of Korean medical science · 2025Article
- Association between metabolic syndrome and the risk of glaucoma: a meta-analysis of observational studies.Diabetology & metabolic syndrome · 2024Article
- The correlation between mitochondrial derived peptide (MDP) and metabolic states: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2024Review
- Insulin resistance in the retina: possible implications for certain ocular diseases.Frontiers in endocrinology · 2024Review
- Designing Covalent Organic Framework-Based Light-Driven Microswimmers toward Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Article
- Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Polygenetic-Risk Scores for A Glaucoma Risk Interact with Blood Pressure, Glucose Control, and Carbohydrate Intake.Nutrients · 2020Article
- Long-term regular exercise and intraocular pressure: the Hisayama Study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.American journal of ophthalmology · 2019Article
- Cholinergic nervous system and glaucoma: From basic science to clinical applications.Progress in retinal and eye research · 2019Review
- Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women.Menopause (New York, N.Y.) · 2018Article
- The synergistic effect of inflammation and metabolic syndrome on intraocular pressure: A cross-sectional study.Medicine · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population.
methodsIn 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP.
resultsThe mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08).
conclusionsThe HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.