ArticleTherapeutics and clinical risk management2015
Are atrophic long-bone nonunions associated with low-grade infections?
Article in Therapeutics and clinical risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- [Tibial defects and infected non-unions : Treatment results after Masquelet technique].Der Orthopade · 2017Trial
- Microbiology, risk factors, and clinical outcomes of low-grade infection in long-bone diaphyseal non-union after open fracture.International orthopaedics · 2026Article
- Systematic investigation and comparison of diagnostic methods in implant-related infections and infectious non-unions in trauma surgery- results of a prospective study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Membrane Filtration of Sonication Fluid-A Promising Adjunctive Method for the Diagnosis of Low-Grade Infection in Presumed Aseptic Nonunion.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Long-Term Outcomes Following Single-Stage Reamed Intramedullary Exchange Nailing in Apparently Aseptic Femoral Shaft Nonunion with Unsuspected Proof of Bacteria.Journal of clinical medicine · 2024Article
- Induced membrane technique versus one-stage autografting in management of atrophic nonunion of long bone in the lower limb: clinical and health burden outcomes.Journal of orthopaedic surgery and research · 2023Article
- Revision risk of salvage compared with acute total hip arthroplasty following femoral neck fracture: an analysis from the Dutch Arthroplasty Register.Acta orthopaedica · 2023Article
- The value of sonication in the differential diagnosis of septic and aseptic femoral and tibial shaft nonunion in comparison to conventional tissue culture and histopathology: a prospective multicenter clinical study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023Article
- Blade Plate With Autogenous Bone Grafting to Salvage Peri Ankle Nonunions.Foot & ankle international · 2023Article
- Effect of Tricalcium Phosphate on Healing of Non-Unions: An Observational Study of over 400 Non-Unions.Therapeutics and clinical risk management · 2023Article
- SPECT/CT Use as an Indicator of Low-Grade Infection in the Spine: Report of Two Cases.The archives of bone and joint surgery · 2023Article
- [Update on non-unions 2022 : Imaging diagnostics, classification and treatment algorithms].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Titanium Wear Particles ExacerbateMicroorganisms · 2021Article
- The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study.Journal of inflammation research · 2021Article
- High prevalence of bacteria in clinically aseptic non-unions of the tibia and the femur in tissue biopsies.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Bacterial Biofilm Components Induce an Enhanced Inflammatory Response Against Metal Wear Particles.Therapeutics and clinical risk management · 2020Article
- Is pseudarthrosis after spinal instrumentation caused by a chronic infection?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Does Age Influence the Outcome of Lower Limb Non-Union Treatment? A Matched Pair Analysis.Journal of clinical medicine · 2019Article
- Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months.Therapeutics and clinical risk management · 2018Article
- [Pseudarthroses of the long bones].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired fracture healing, especially when associated with bacterial infection, is a severe complication following long-bone fractures and requires special treatment. Because standard diagnostic techniques might provide falsely negative results, we evaluated the sonication method for detection of bacteria on implants of patients with fracture nonunions. A total of 49 patients with a nonunion (group NU) and, for comparison, 45 patients who had undergone routine removal of osteosynthetic material (group OM), were included in the study. Five different diagnostic methods (culture of tissue samples, culture of intraoperative swabs, histopathology of tissue samples, culture of sonication fluid, and 16S ribosomal DNA polymerase chain reaction of sonication fluid) were compared and related to clinical data. Among the diagnostic tests, culture of sonication fluid demonstrated by far the highest detection rate of bacteria (57%) in group NU, and rather unexpectedly 40% in group OM. Culture of sonication samples also revealed a broad spectrum of bacteria, in particular Propionibacterium spp. In conclusion, our results indicate that more bacteria can be detected on implants of patients with atrophic nonunions of long-bone fractures by means of the sonication procedure, which provides a valuable additional diagnostic tool to decide on a surgical procedure (eg, two-step procedure) and to further specify antimicrobial therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.