ArticleNeuropsychiatric disease and treatment2015
Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 45 citations in OpenAlex.
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- Alterations in surface-based amplitude of low-frequency fluctuations primary open-angle glaucoma link to neurotransmitter profiling and visual impairment severity.Brain imaging and behavior · 2025Article
- Functional MRI in optic neuritis: insights into cortical modulation and possible recovery mechanisms.Frontiers in neurology · 2025Review
- Impaired interhemispheric synchrony in patients with iridocyclitis and classification using machine learning: an fMRI study.Frontiers in immunology · 2024Article
- Altered functional connectivity of the default mode network in non-arteritic anterior ischaemic optic neuropathy.Brain communications · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Spontaneous changes in brain network centrality in patients with pathological myopia: A voxel-wise degree centrality analysis.CNS neuroscience & therapeutics · 2023Article
- Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Voxel-Mirrored Homotopic Connectivity Is Altered in Meibomian Gland Dysfunction Patients That Are Morbidly Obese.Brain sciences · 2022Article
- Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis.Journal of clinical medicine · 2022Article
- The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction.Frontiers in neuroscience · 2022Article
- Resting-state functional MRI of the visual system for characterization of optic neuropathy.Frontiers in human neuroscience · 2022Review
- Altered Brain Activity in Patients With Comitant Strabismus Detected by Analysis of the Fractional Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study.Frontiers in human neuroscience · 2022Article
- Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study.Scientific reports · 2021Article
- Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low-frequency fluctuations: A functional magnetic resonance imaging study.Brain and behavior · 2021Article
- Altered brain network centrality in middle-aged patients with retinitis pigmentosa: A resting-state functional magnetic resonance imaging study.Brain and behavior · 2021Article
- Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study.Disease markers · 2021Article
- Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis.Frontiers in neuroscience · 2021Article
- Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study.International journal of ophthalmology · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the local features of spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance. MATERIALS AND
methodsTwelve patients with ON (four male, eight female) and twelve age-, sex-, and education status-matched healthy controls (HCs) (four male, eight female) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF technique was used to assess local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ALFF values of the different areas and visual evoked potentials (VEPs) in patients with ON.
resultsCompared with HCs, patients with ON had significantly decreased ALFF values in the posterior and anterior lobes of the right cerebellum, right putamen, right inferior frontal gyrus, right insula, right supramarginal gyrus, right inferior parietal lobule, left medial frontal gyrus, left superior temporal gyrus, bilateral anterior cingulate/medial frontal gyrus, and bilateral precuneus, and significantly increased ALFF values in the posterior lobes of the left and right cerebellum, right inferior temporal gyrus, right inferior temporal/fusiform gyrus, left parahippocampal gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. We found negative correlations between the mean ALFF signal value of the left parahippocampal gyrus and the VEP amplitude of the right eye in ON (r=-0.584, P=0.046), and a positive correlation between the mean ALFF signal value of the bilateral precuneus and the best-corrected visual acuity of the left eye (r=0.579, P=0.048) in patients with ON.
conclusionON mainly seems to involve dysfunction in the default-mode network, cerebellum, and limbic system, which may reflect the underlying pathologic mechanism of ON.
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