ArticleDrug design, development and therapy2015
Study of bone-like hydroxyapatite/polyamino acid composite materials for their biological properties and effects on the reconstruction of long bone defects.
Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Wood as Possible Renewable Material for Bone Implants-Literature Review.Journal of functional biomaterials · 2023Review
- Bioactive glass doped with noble metal nanoparticles for bone regeneration:RSC advances · 2021Article
- Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview.Journal of orthopaedic translation · 2020Review
- Interrelationships among hydrogen permeation, physiochemical properties and early adsorption abilities of titanium.Journal of materials science. Materials in medicine · 2017Article
- Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions.Science advances · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the effect of bone-like hydroxyapatite/polyamino acid (BHA/PAA) in the osteogenesis and reconstruction of long segmental bone defects.
methodsIn vitro, MG63 cells were cultured with BHA/PAA. The osteoinductive activity of the BHA/PAA material was evaluated using inverted microscopy, scanning electron microscopy, MTT proliferation assay, and the determination of alkaline phosphatase activity and Ca(2+) content. In vivo, the radial bone defect was made in 20 New Zealand White rabbits, and then these animal were randomly divided into two groups (n=10), the experimental group (with BHA/PAA) and the control group (without BHA/PAA). Postoperatively, the osteogenesis effect of BHA/PAA was evaluated through X-ray, hematoxylin-eosin staining, observation of the gross bone specimen, immunohistochemistry, and fluorescent confocal scanning microscopy.
resultsIn vitro, BHA/PAA promoted the adhesion, growth, and calcium nodule formation of MG63 cells, and it had good osteogenesis activity. In vivo, with BHA/PAA material degradation and absorption, the new bone gradually formed, and the bone defect gradually recovered in the experimental group. In the control group, a limited bone formation was found at the bone broken ends, and the bone defect was obviously visible.
conclusionIn vitro and in vivo, we confirmed that BHA/PAA was effective in inducing osteogenesis and reconstructing a long segmental bone defect.
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Registered trials
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