ArticleAnnals of dermatology2015
Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles.
Article in Annals of dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- KyohMolecules (Basel, Switzerland) · 2025Article
- Synergistic Phytochemical and Pharmacological Actions of Hair RisePlants (Basel, Switzerland) · 2024Article
- Article
- Role and Mechanisms of Phytochemicals in Hair Growth and Health.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Activation of Hair Cell Growth Factors by Linoleic Acid inMolecules (Basel, Switzerland) · 2021Article
- Polysaccharide Extracted fromPolymers · 2020Article
- An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum.The Journal of clinical and aesthetic dermatology · 2020Article
- Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Improvement of Cell Proliferation and Antioxidant Activity of Silymarin in Hair Follicles Dermal Papillae Isolated from the Human Scalp: Comparison with Vitamin C Effects.International journal of trichologyArticle
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe number of people suffering from balding or hair thinning is increasing, despite the advances in various medical therapies. Therefore, it is highly important to develop new therapies to inhibit balding and increase hair proliferation.
objectiveWe investigated the effects of herbal extracts commonly used for improving balding in traditional medicine to identify potential agents for hair proliferation.
methodsThe expression levels of 5α-reductase isoforms (type I and II) were analyzed using quantitative real-time reverse transcription polymerase chain reaction in the human follicular dermal papilla cells (DPCs). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylteterazolium bromide and bromodeoxyuridine tests were used to evaluate the cell proliferation effect of herbal extracts in DPCs. The expression levels of extracellular signal-regulated kinase (ERK), Akt, cyclin D1, cyclin-dependent kinase 4 (Cdk4), B-cell lymphoma (Bcl-2) and Bcl-2-associated X protein (Bax) were measured using western blot analysis.
resultsThe 5α-reductase isoform mRNAs and proteins were detected in the cultured DPCs, and the expression level of 5α-R2 in DPCs in the presence of the herbal extracts was gradually decreased. Herbal extracts were found to significantly increase the proliferation of human DPCs at concentrations ranging from 1.5% to 4.5%. These results show that the herbal extracts tested affected the protein expressions of ERK, Akt, cyclin D1, Cdk4, Bcl-2, and Bax in DPCs.
conclusionThese results suggest that herbal extracts exert positive effects on hair proliferation via ERK, Akt, cyclin D1, and Cdk4 signaling in DPCs; they also suggest that herbal extracts could be a great alternative therapy for increasing hair proliferation.
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Registered trials
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