Evidence map›Paper›PMID 26719530›Full record

ArticleCancer research2016

An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers.

Robyn L Prueitt, Tiffany A Wallace, Sharon A Glynn, Ming Yi, Wei Tang, Jun Luo, Tiffany H Dorsey, Katherine E Stagliano, John W Gillespie, Robert S Hudson and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Targeting Glutamine Metabolism in Prostate Cancer.Frontiers in bioscience (Elite edition) · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Multi-Omics Analysis of the Effects of Smoking on Human Tumors.Frontiers in molecular biosciences · 2021
    Article
  14. Functional Silencing ofClinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
  15. Clinical cancer research : an official journal of the American Association for Cancer Research · 2018
    Article
  16. Review
  17. Article
  18. Linking Race, Cancer Outcomes, and Tissue Repair.The American journal of pathology · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 1 country.

Robyn L Prueitt *Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Tiffany A Wallace *Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Sharon A Glynn *Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Ming YiAdvanced Biomedical Computing Center, Leidos Biomedical Research/NCI, Frederick, MD, USA.
Wei TangLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Jun LuoDepartment of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Tiffany H DorseyLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Katherine E StaglianoLaboratory of Molecular Immunoregulation, CCR, NCI, NIH, Frederick, MD, USA.
John W GillespieLaboratory of Pathology and Urologic Oncology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Robert S HudsonLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Atsushi TerunumaLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Jennifer L ShoeLaboratory Animal Sciences Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD, USA.
Diana C HainesPathology/Histotechnology Laboratory, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD, USA.
Harris G YfantisPathology and Laboratory Medicine, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Misop HanDepartment of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Damali N MartinLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Symone V JordanLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
James F BorinUrology and Greenebaum Cancer Center, University of Maryland, MD, USA.
Michael J NaslundUrology and Greenebaum Cancer Center, University of Maryland, MD, USA.
Richard B AlexanderUrology and Greenebaum Cancer Center, University of Maryland, MD, USA.
Robert M StephensAdvanced Biomedical Computing Center, Leidos Biomedical Research/NCI, Frederick, MD, USA.
Christopher A LoffredoCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Dong H LeePathology and Laboratory Medicine, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Nagireddy PutluriDepartment of Molecular and Cell Biology, Verna and Marrs McLean Department of Biochemistry, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA.
Arun SreekumarDepartment of Molecular and Cell Biology, Verna and Marrs McLean Department of Biochemistry, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA.
Arthur A HurwitzLaboratory of Pathology and Urologic Oncology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Center for Cancer Research · USLeidos (United States) · USUniversity of Maryland, Baltimore · USBaltimore VA Medical Center · USBaylor College of Medicine · USJohns Hopkins University · USOffice of Extramural Research · USGeorgetown University · US

Funding

Maryland Prostate Cancer Case-Control StudyZIABC010499 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.4M
METABOLOMIC PROFILING AND BIOLOGIC BASIS OF RACIAL DISPARITY IN PROSTATE CANCERU01CA167234 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PALAPATTU, GANESH S, SREEKUMAR, ARUN · 2012 to 2016
$1.9M
Maryland Prostate Cancer Case-Control StudyZ01BC010499 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2003 to 2008
$1.2M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 BC010499NCI NIH HHS HHSN261200800001ENCI NIH HHS U01 CA167234
6 · The paper itself

Abstract

Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never smokers. By this route, we elucidated a distinct pattern of molecular alterations characterized by an immune and inflammation signature in tumors from current smokers that were either attenuated or absent in past and never smokers. Specifically, this signature included elevated immunoglobulin expression by tumor-infiltrating B cells, NF-κB activation, and increased chemokine expression. In an alternate approach to characterize smoking-induced oncogenic alterations, we also explored the effects of nicotine in human prostate cancer cells and prostate cancer-prone TRAMP mice. These investigations showed that nicotine increased glutamine consumption and invasiveness of cancer cells in vitro and accelerated metastatic progression in tumor-bearing TRAMP mice. Overall, our findings suggest that nicotine is sufficient to induce a phenotype resembling the epidemiology of smoking-associated prostate cancer progression, illuminating a novel candidate driver underlying metastatic prostate cancer in current smokers.

Indexed as

TranscriptomeAnimalsCell Line, TumorCell NucleusHumansImmunoglobulinsInflammationInterleukin-8MaleMiceNeoplasm InvasivenessNeoplasm MetastasisNF-kappa BNicotineProstatic NeoplasmsProto-Oncogene Proteins c-aktImmunoglobulinsInterleukin-8NF-kappa BNicotineProto-Oncogene Proteins c-akt

Identifiers

PMID26719530
PMCPMC4775384
OpenAlexW2279863755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.