Evidence map›Paper›PMID 26719440›Full record

ArticleJournal of clinical microbiology2016

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam-β-Lactamase Inhibitor Combinations.

Gina K Thomson, James W Snyder, Christi L McElheny, Kenneth S Thomson, Yohei Doi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. An outbreak of blaAntimicrobial resistance and infection control · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Further Spread of aFrontiers in microbiology · 2018
    Article
  7. Article
  8. Article
  9. The rapid spread of carbapenem-resistant Enterobacteriaceae.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Gina K ThomsonDepartment of Microbiology, University of Louisville Hospital, Louisville, Kentucky, USA Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA.
James W SnyderDepartment of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA.
Christi L McElhenyDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kenneth S ThomsonDepartment of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA.
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA yod4@pitt.edu.
University of Louisville · USUniversity of Pittsburgh · USUniversity of Louisville Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Markers predicting response to therapy for KPC-producing Klebsiella pneumoniaeR21AI107302 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2013 to 2014
$409k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI104895NIAID NIH HHS R01AI104895NIAID NIH HHS R21 AI107302NIAID NIH HHS R21AI107302
6 · The paper itself

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla(KPC-18) and bla(VIM-1). Whole-genome sequencing localized bla(KPC-18) to the chromosome and bla(VIM-1) to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam-β-lactamase inhibitor combinations.

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsDrug Resistance, BacterialEnterobacter cloacaeEnterobacteriaceae InfectionsGene OrderGenetic LociHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-Lactamscarbapenemase

Identifiers

PMID26719440
PMCPMC4767958
OpenAlexW2214408968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.