Evidence map›Paper›PMID 26719436›Full record

ArticleJournal of clinical microbiology2016

Preclinical Assessment of a Fully Automated Multiplex PCR Panel for Detection of Central Nervous System Pathogens.

K E Hanson, E S Slechta, J A Killpack, C Heyrend, T Lunt, J A Daly, A C Hemmert, A J Blaschke

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Review
  3. Review
  4. Real-World Evaluation of the BioFire FilmArray ME Panel: Diagnostic Accuracy and Clinical Utility.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Group B Streptococcal Neonatal Meningitis.Clinical microbiology reviews · 2022
    Review
  13. Observational
  14. Article
  15. Article
  16. Impact of cerebrospinal fluid syndromic testing in the management of children with suspected central nervous system infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K E HansonUniversity of Utah Department of Medicine, Division of Infectious Diseases, School of Medicine, Salt Lake City, Utah, USA University of Utah Department of Pathology, Clinical Microbiology, Salt Lake City, Utah, USA kim.hanson@hsc.utah.edu anne.blaschke@hsc.utah.edu.
E S SlechtaARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.
J A KillpackUniversity of Utah Department of Pediatrics, Division of Pediatric Infectious Diseases, Salt Lake City, Utah, USA.
C HeyrendIntermountain Primary Children's Hospital, Salt Lake City, Utah, USA.
T LuntARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.
J A DalyUniversity of Utah Department of Pathology, Clinical Microbiology, Salt Lake City, Utah, USA Intermountain Primary Children's Hospital, Salt Lake City, Utah, USA.
A C HemmertBioFire Diagnostics, LLC, Salt Lake City, Utah, USA.
A J BlaschkeUniversity of Utah Department of Pediatrics, Division of Pediatric Infectious Diseases, Salt Lake City, Utah, USA kim.hanson@hsc.utah.edu anne.blaschke@hsc.utah.edu.

Funding

Rapid, automated, detection of viral and bacterial pathogens causing meningitisR43AI104029 · NIAID · BIOFIRE DEFENSE, LLC. · PI HEMMERT, ANDREW · 2013 to 2014
$453k
Intramural NIH HHSNIAID NIH HHS 5R43AI104029-02NIAID NIH HHS R43 AI104029
6 · The paper itself

Abstract

We evaluated a multiplexed PCR panel for the detection of 16 bacterial, viral, and fungal pathogens in cerebrospinal fluid. Panel results were compared to routine testing, and discrepancies were resolved by additional nucleic acid amplification tests or sequencing. Overall, the positive and negative agreements across methods were 92.9% and 91.9%, respectively.

Indexed as

AutomationMultiplex Polymerase Chain ReactionCentral Nervous System InfectionsHumansReagent Kits, DiagnosticReproducibility of ResultsSensitivity and SpecificityReagent Kits, Diagnostic

Identifiers

PMID26719436
PMCPMC4767945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.