ArticleProceedings of the National Academy of Sciences of the United States of America2016
Ultrasensitive surface-enhanced Raman scattering detection in common fluids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed.
- Coronamicroparticle Arrays with Stable Superamphiphobicity.Small methods · 2026Article
- Ultrasensitive Chemical Detection Using Integrating Cavity-Enhanced Raman Spectroscopy.Analytical chemistry · 2026Article
- Reconfigurable Nanogap SERS for Multiscale Molecular Sensing on Curved Surfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Rapid Identification of Trace Pharmacodynamic Substances in Traditional Chinese Medicine via SERS and Deep Learning.Biosensors · 2026Article
- Facile Scalable Assembly of Uniform and Layered Plasmonic Hotspots by Force-Assisted Capillary-Mediated Colloidal Transfer.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Digitally fabricated 3D slippery architectures for multifunctional liquid manipulation.Nature communications · 2025Article
- Rapid, On-Site SARS-CoV‑2 Variant Detection and Differentiation Using GLAD-Pristine Silver Nanorod Arrays and Machine Learning-Enhanced SERS.ACS omega · 2025Article
- Advances in Wettability-Engineered Open Planar-Surface Droplet Manipulation.Micromachines · 2025Review
- A Microfluidic Device to Realize Electrochemically Controlled SERS Detection in HPLC.Analytical chemistry · 2025Article
- Single-Base Detection of DNA with Simplified Steps on InGaN Quantum Wells.The journal of physical chemistry. B · 2025Article
- Hybrid Metasurface for On-Chip Enrichment and Quantification of Biological Samples.ACS applied materials & interfaces · 2025Article
- Metasurface-enhanced biomedical spectroscopy.Nanophotonics (Berlin, Germany) · 2025Review
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Plasmonic Slippery Surface for Surface-Enhanced Raman Spectroscopy and Protein Adsorption Inhibition.Analytical chemistry · 2025Article
- Nanostructured Surfaces with Plasmonic Activity and Superhydrophobicity: Review of Fabrication Strategies and Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Microplasma Controlled Nanogold Sensor for SERS of Aliphatic and Aromatic Explosives with PCA-KNN Recognition.ACS sensors · 2025Article
- Rapid drug detection equipment based on molecular imprinting and surface plasmon resonance technology.Frontiers in chemistry · 2025Article
- Machine Learning-Assisted Surface-Enhanced Raman Spectroscopy Detection for Environmental Applications: A Review.Environmental science & technology · 2024Review
- Ultrasensitive Surface-Enhanced Raman Scattering Platform for Protein Detection via Active Delivery to Nanogaps as a Hotspot.ACS nano · 2024Article
- Flexible 3D Plasmonic Web Enables Remote Surface Enhanced Raman Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting target analytes with high specificity and sensitivity in any fluid is of fundamental importance to analytical science and technology. Surface-enhanced Raman scattering (SERS) has proven to be capable of detecting single molecules with high specificity, but achieving single-molecule sensitivity in any highly diluted solutions remains a challenge. Here we demonstrate a universal platform that allows for the enrichment and delivery of analytes into the SERS-sensitive sites in both aqueous and nonaqueous fluids, and its subsequent quantitative detection of Rhodamine 6G (R6G) down to ∼75 fM level (10(-15) mol⋅L(-1)). Our platform, termed slippery liquid-infused porous surface-enhanced Raman scattering (SLIPSERS), is based on a slippery, omniphobic substrate that enables the complete concentration of analytes and SERS substrates (e.g., Au nanoparticles) within an evaporating liquid droplet. Combining our SLIPSERS platform with a SERS mapping technique, we have systematically quantified the probability, p(c), of detecting R6G molecules at concentrations c ranging from 750 fM (p > 90%) down to 75 aM (10(-18) mol⋅L(-1)) levels (p ≤ 1.4%). The ability to detect analytes down to attomolar level is the lowest limit of detection for any SERS-based detection reported thus far. We have shown that analytes present in liquid, solid, or air phases can be extracted using a suitable liquid solvent and subsequently detected through SLIPSERS. Based on this platform, we have further demonstrated ultrasensitive detection of chemical and biological molecules as well as environmental contaminants within a broad range of common fluids for potential applications related to analytical chemistry, molecular diagnostics, environmental monitoring, and national security.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.