Evidence map›Paper›PMID 26719359›Full record

ArticleHeart (British Cardiac Society)2016

Pregnancy course and outcomes in women with arrhythmogenic right ventricular cardiomyopathy.

Anke R Hodes, Crystal Tichnell, Anneline S J M Te Riele, Brittney Murray, Judith A Groeneweg, Abhishek C Sawant, Stuart D Russell, Karin Y van Spaendonck-Zwarts, Maarten P van den Berg, Arthur A Wilde and 6 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Pregnancy in arrhythmogenic cardiomyopathy.Herzschrittmachertherapie & Elektrophysiologie · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Cardiomyopathy and pregnancy.Heart (British Cardiac Society) · 2019
    Review
  17. Article
  18. Diagnostic and therapeutic strategies for arrhythmogenic right ventricular dysplasia/cardiomyopathy patient.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2019
    Review
  19. Article
  20. Cardiac Arrhythmias and Pregnancy.Current treatment options in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Anke R HodesDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Department of Cardiology/Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Crystal TichnellDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Anneline S J M Te RieleDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Brittney MurrayDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Judith A GroenewegDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands.
Abhishek C SawantDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Stuart D RussellDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Karin Y van Spaendonck-ZwartsDepartment of Genetics, Academic Medical Center, Amsterdam, The Netherlands.
Maarten P van den BergDepartment of Cardiology/Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Arthur A WildeDepartment of Clinical and Experimental Cardiology, Heart Centre, Academic Medical Centre, Amsterdam, The Netherlands.
Harikrishna TandriDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Daniel P JudgeDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Richard N W HauerInteruniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands.
Hugh CalkinsDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
J Peter van TintelenDepartment of Cardiology/Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands Department of Genetics, Academic Medical Center, Amsterdam, The Netherlands.
Cynthia A JamesDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USAcademic Medical Center · NLNetherlands Heart Institute · NLUniversity Medical Center Utrecht · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo characterise pregnancy course and outcomes in women with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C).

methodsFrom a combined Johns Hopkins/Dutch ARVD/C registry, we identified 26 women affected with ARVD/C (by 2010 Task Force Criteria) during 39 singleton pregnancies >13 weeks (1-4 per woman). Cardiac symptoms, treatment and episodes of sustained ventricular arrhythmias (VAs) and heart failure (HF) ≥ Class C were characterised. Obstetric outcomes were ascertained. Incidence of VA and HF were compared with rates in the non-pregnant state. Long-term disease course was compared with 117 childbearing-aged female patients with ARVD/C who had not experienced pregnancy with ARVD/C.

resultsTreatment during pregnancy (n=39) included β blockers (n=16), antiarrhythmics (n=6), diuretics (n=3) and implantable cardioverter defibrillators (ICDs) (n=28). In five pregnancies (13%), a single VA occurred, including two ICD-terminated events. Arrhythmias occurred disproportionately in probands without VA history (p=0.045). HF, managed on an outpatient basis, developed in two pregnancies (5%) in women with pre-existing overt biventricular or isolated right ventricular disease. All infants were live-born without major obstetric complications. Caesarean sections (n=11, 28%) had obstetric indications, except one (HF). β Blocker therapy was associated with lower birth weight (3.1±0.48 kg vs 3.7±0.57 kg; p=0.002). During follow-up children remained healthy (median 3.4 years), and mothers were without cardiac mortality or transplant. Neither VA nor HF incidence was significantly increased during pregnancy. ARVD/C course (mean 6.5±5.6 years) did not differ based on pregnancy history.

conclusionsWhile most pregnancies in patients with ARVD/C were tolerated well, 13% were complicated by VA and 5% by HF.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaLive BirthPregnancy Complications, CardiovascularAdultAnti-Arrhythmia AgentsArrhythmias, CardiacBaltimoreCase-Control StudiesCesarean SectionChild DevelopmentChild, PreschoolDefibrillators, ImplantableElectric CountershockFemaleHeart FailureHumansAnti-Arrhythmia Agents

Identifiers

PMID26719359
PMCPMC4752646
OpenAlexW2226349713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.