Evidence map›Paper›PMID 26719281›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2017

Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients.

Shannon B Donnola, Elliott C Dasenbrook, David Weaver, Lan Lu, Karishma Gupta, Anjali Prabhakaran, Xin Yu, James F Chmiel, Kimberly McBennett, Michael W Konstan and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Paediatric lung imaging: the times they are a-changin'.European respiratory review : an official journal of the European Respiratory Society · 2018
    Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shannon B DonnolaDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Elliott C DasenbrookDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
David WeaverDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Lan LuDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA; Department of Urology, Case Western Reserve University, Cleveland, OH, USA.
Karishma GuptaDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Anjali PrabhakaranLake Ridge Academy, North Ridgeville, OH, USA.
Xin YuDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
James F ChmielDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Kimberly McBennettDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Michael W KonstanDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Mitchell L DrummDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Genetics, Case Western Reserve University, Cleveland, OH, USA.
Chris A FlaskDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address: caf@case.edu.
Case Western Reserve University · USRainbow Babies & Children's Hospital · USLake Forest Academy · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Translational Research in Cystic FibrosisP30DK027651 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L · 1986 to 2014
$15.6M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
MRI Imaging Biomarkers of ARPKD Kidney and Liver DiseaseR01DK085099 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DELL, KATHERINE MACRAE, FLASK, CHRISTOPHER A · 2011 to 2015
$1.6M
Case Incubator and Multidisciplinary Urologic Research Groups (CIMURG) in Women'sK12DK100014 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DANESHGARI, FIROUZ · 2013 to 2017
$1.5M
NCATS NIH HHS UL1 TR000439NCI NIH HHS P30 CA043703NIDDK NIH HHS K12 DK100014NIDDK NIH HHS P30 DK027651NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK085099
6 · The paper itself

Abstract

backgroundPrevious studies have shown that Magnetic Resonance Imaging (MRI) techniques can be used to non-invasively assess lung disease in CF patients. In this study, we compare the sensitivity of normalized T1 (nT1) and non-contrast perfusion MRI techniques to detect regional lung disease in CF patients. MATERIALS AND

methodsMRI data were obtained for eight adult CF patients without overt pulmonary exacerbation (FEV1=45-127%) and six healthy volunteers on a Siemens Espree 1.5T MRI scanner. Sagittal nT1 and perfusion data were acquired for each subject's left and right lungs. A region-of-interest analysis was used to calculate mean nT1 and perfusion values in the individual lobes of the left and right lungs for each subject.

resultsIn comparison to healthy controls, CF subjects showed a significant decrease in nT1 values in the upper lobe of the left lung as well as in the upper and anterior lobes of the right lung (p<0.001). Similar nT1 differences were observed with in the CF cohort in comparison to their respective posterior lobes (p<0.001). Pulmonary perfusion for the CF subjects was also significantly reduced in the upper lobe of the right lung (p<0.05). Significant correlations with spirometry were also observed for both nT1 (left upper lobe: p<0.01) and perfusion (left and right upper lobes (p≤0.05)). Additionally, significant correlations were observed between nT1 and perfusion in the upper lobes of the left (p=0.05) and right lungs (p=0.005).

conclusionsThis pilot study confirms that both the nT1 and non-contrast perfusion MRI techniques can sensitively detect regional lung changes in patients with CF. While both imaging methods were able to detect regional lung disease, the additional nT1 reductions in the CF patients suggests that nT1 may be more sensitive to regional CF lung disease.

Indexed as

Cystic FibrosisAdultCross-Sectional StudiesEarly DiagnosisFemaleHumansLungMagnetic Resonance AngiographyMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRespiratory Function TestsSensitivity and SpecificitySeverity of Illness IndexImagingLung diseaseMagnetic Resonance ImagingPerfusionRelaxometry

Identifiers

PMID26719281
PMCPMC4916031
OpenAlexW2220277228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.