Evidence map›Paper›PMID 26719255›Full record

ArticleJournal of virology2015

Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines.

Anna Godi, Alessandra Facchetti, Sara L Bissett, Clementina Cocuzza, Elizabeth Miller, Simon Beddows

Abstract read
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna GodiVirus Reference Department, Public Health England, London, United Kingdom.
Alessandra FacchettiVirus Reference Department, Public Health England, London, United Kingdom Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy.
Sara L BissettVirus Reference Department, Public Health England, London, United Kingdom.
Clementina CocuzzaDepartment of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy.
Elizabeth MillerNational Vaccine Evaluation Consortium, Public Health England, London, United Kingdom.
Simon BeddowsVirus Reference Department, Public Health England, London, United Kingdom simon.beddows@phe.gov.uk.

Funding

Department of Health 039/0031
6 · The paper itself

Abstract

We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.

Indexed as

Cross ReactionsGenetic VariationAlphapapillomavirusAntibodies, NeutralizingAntibodies, ViralCapsid ProteinsHumansNeutralization TestsPapillomavirus VaccinesAntibodies, NeutralizingAntibodies, ViralCapsid ProteinsPapillomavirus Vaccines

Identifiers

PMID26719255
PMCPMC4810639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.