ReviewMedical & biological engineering & computing2016
Mathematical models of wound healing and closure: a comprehensive review.
Review in Medical & biological engineering & computing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Open Pilonidal Excision as a Translational Human Model for Wound Healing and Skin Regeneration Research.Biomedicines · 2026Review
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- A Mathematical Model of Wound Healing Incorporating Strain-Induced MSC Differentiation.Annals of biomedical engineering · 2026Article
- A Simple Framework for Agent-Based Modeling with Extracellular Matrix.Bulletin of mathematical biology · 2025Article
- Research trends and hot topics of wearable sensors in wound care over past 18 years: A bibliometric analysis.Heliyon · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Semi-autonomous wound invasion via matrix-deposited, haptotactic cues.Journal of theoretical biology · 2023Article
- On the role of myosin-induced actin depolymerization during cell migration.Molecular biology of the cell · 2023Article
- Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues.International journal of molecular sciences · 2022Review
- Mechanobiological wound model for improved design and evaluation of collagen dermal replacement scaffolds.Acta biomaterialia · 2021Article
- Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing.Bulletin of mathematical biology · 2021Article
- Multi-scale analysis and modelling of collective migration in biological systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Model-Based Analysis Reveals a Sustained and Dose-Dependent Acceleration of Wound Healing by VEGF-A mRNA (AZD8601).CPT: pharmacometrics & systems pharmacology · 2020Article
- Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing.Journal of medicinal chemistry · 2018Article
- Review on experiment-based two- and three-dimensional models for wound healing.Interface focus · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a complex process comprised of overlapping phases and events that work to construct a new, functioning tissue. Mathematical models describe these events and yield understanding about the overall process of wound healing. Generally, these models are focused on only one phase (or a few phases) to explain healing for a specific system. A review of the literature reveals insights as reported on herein regarding the variety of overlapping inputs and outputs for any given type of model. Specifically, these models have been characterized with respect to the phases of healing and their mathematical/physical basis in an effort to shed light on new opportunities for model development. Though all phases of wound healing have been modeled, previous work has focused mostly on the proliferation and related contraction phases of healing with fewer results presented regarding other phases. As an example, a gap in the literature has been identified regarding models to describe facilitated wound closure techniques (e.g., suturing and its effect on resultant scarring). Thus, an opportunity exists to create models that tie the transient processes of wound healing, such as cell migration, to resultant scarring when considering tension applied to skin with given suturing techniques.
Indexed as
Identifiers
26718553What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.