ArticleVision research2016
Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes.
Article in Vision research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Modulation of narrow-field amacrine cells on light-evoked spike responses and receptive fields of retinal ganglion cells.Vision research · 2023Article
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Rod and Cone Connections With Bipolar Cells in the Rabbit Retina.Frontiers in cellular neuroscience · 2021Article
- Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation.Investigative ophthalmology & visual science · 2020Article
- Atypical visual processing in a mouse model of autism.Scientific reports · 2020Article
- Glycinergic and GABAergic interneurons shift the location and differentially alter the size of ganglion cell receptive field centers in the mammalian retina.Vision research · 2020Article
- Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.Human molecular genetics · 2020Article
- Genetic dissection of rod and cone pathways mediating light responses and receptive fields of ganglion cells in the mouse retina.Vision research · 2020Article
- Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice.NPJ microgravity · 2020Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Mild Intraocular Pressure Elevation in Mice Reveals Distinct Retinal Ganglion Cell Functional Thresholds and Pressure-Dependent Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Parallel Processing of Rod and Cone Signals: Retinal Function and Human Perception.Annual review of vision science · 2018Review
- Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice.Scientific reports · 2018Article
- Elevated IOP alters the space-time profiles in the center and surround of both ON and OFF RGCs in mouse.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina.Scientific reports · 2017Article
- Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.Annual review of neuroscience · 2017Review
- Article
- Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Rod pathways are a parallel set of synaptic connections which enable night vision by relaying and processing rod photoreceptor light responses. We use dim light stimuli to isolate rod pathway contributions to downstream light responses then characterize these contributions in knockout mice lacking rod transducin-α (Trα), or certain pathway components associated with subsets of rod pathways. These comparisons reveal that rod pathway driven light sensitivity in retinal ganglion cells (RGCs) is entirely dependent on Trα, but partially independent of connexin 36 (Cx36) and rod bipolar cells. Pharmacological experiments show that rod pathway-driven and Cx36-independent RGC ON responses are also metabotropic glutamate receptor 6-dependent. To validate the RGC findings in awake, behaving animals we measured optokinetic reflexes (OKRs), which are sensitive to changes in ON pathways. Scotopic OKR contrast sensitivity was lost in Trα(-/-) mice, but indistinguishable from controls in Cx36(-/-) and rod bipolar cell knockout mice. Mesopic OKRs were also altered in mutant mice: Trα(-/-) mice had decreased spatial acuity, rod BC knockouts had decreased sensitivity, and Cx36(-/-) mice had increased sensitivity. These results provide compelling evidence against the complete Cx36 or rod BC dependence of night vision's ON component. Further, the findings suggest the parallel nature of rod pathways provides considerable redundancy to scotopic light sensitivity but distinct contributions to mesopic responses through complicated interactions with cone pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.