ArticleSurgical endoscopy2016
The Ki-67 labeling index and lymphatic/venous permeation predict the metastatic potential of rectal neuroendocrine tumors.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Rectal neuroendocrine tumors: Update.World journal of gastrointestinal oncology · 2026Review
- Endoscopic treatment of rectal neuroendocrine tumors: a consecutive analysis of multi-institutional data.Annals of coloproctology · 2025Article
- Review
- Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future.Endocrine pathology · 2023Review
- Liver metastasis from rectal neuroendocrine neoplasm detected 15 years after primary resection.Surgical case reports · 2022Article
- Rectal neuroendocrine neoplasms: what the radiologists should know.Abdominal radiology (New York) · 2022Review
- New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastroenterology · 2022Review
- Risk factors for lymph node metastasis and prognosis in colorectal neuroendocrine tumours.International journal of colorectal disease · 2022Article
- Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms: The NOVARA Score, a Multicentre Retrospective Study.Journal of clinical medicine · 2022Article
- MRI-detected extramural venous invasion of rectal cancer: Multimodality performance and implications at baseline imaging and after neoadjuvant therapy.Insights into imaging · 2021Review
- Neuroendocrine neoplasms of the appendix, colon and rectum.Pathologica · 2021Review
- Clinicopathological heterogeneity between primary and metastatic sites of gastroenteropancreatic neuroendocrine neoplasm.Diagnostic pathology · 2020Article
- A novel risk-scoring system for predicting lymph node metastasis of rectal neuroendocrine tumors.Annals of gastroenterological surgery · 2020Article
- Endoscopic submucosal resection with an endoscopic variceal ligation device for the treatment of rectal neuroendocrine tumors.International journal of colorectal disease · 2018Article
- Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.Virchows Archiv : an international journal of pathology · 2018Review
- A 10-year History of a Diminutive Rectal Neuroendocrine Tumor.Internal medicine (Tokyo, Japan) · 2018Article
- Predictive Factors for Lymph Node Metastasis and Prognostic Factors for Survival in Rectal Neuroendocrine Tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic resection has been used to treat small rectal neuroendocrine tumors (NETs). However, the indication for additional surgery after endoscopic resection is unclear. The aim of this study was to identify risk factors for rectal NET metastasis and to determine the indication for additional surgery.
methodsFifty-five patients with a total of 57 rectal NETs, treated between October 2003 and January 2013, were retrospectively divided into metastatic (11 lesions) and non-metastatic (46 lesions) groups. Tumor size, central depression, invasion depth, lymphatic and venous permeation, mitotic activity, nuclear abnormality, Ki-67 labeling index, and World Health Organization grading classification (G1 or G2) were compared between the groups. Patients underwent endoscopic submucosal resection with a ligation device, transanal full-thickness surgical resection, or radical surgery.
resultsBy univariate analysis, the odds ratios (OR) for a Ki-67 labeling index >3.0 %, positive lymphatic or venous permeation, World Health Organization grading classification G2, tumor size >10 mm, submucosal invasion >4000 μm, and central depression were 120 (P < 0.001), 67.6 (P < 0.001), 58.7 (P < 0.001), 9.8 (P = 0.0037), 6.8 (P = 0.012), and 5.7 (P = 0.018), respectively. Multivariate logistic regression analyses showed that vascular permeation (OR 111; P = 0.006) and a Ki-67 labeling index >3.0 % (OR 88; P = 0.012) were independent risk factors for metastasis.
conclusionsThe Ki-67 labeling index and lymphatic/venous permeation were reliable predictors of rectal NET metastases.
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