Evidence map›Paper›PMID 26718236›Full record

ArticleArchives of physical medicine and rehabilitation2016

Respiratory Training Improves Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury.

Sevda C Aslan, David C Randall, Andrei V Krassioukov, Aaron Phillips, Alexander V Ovechkin

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04210063 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Inspiratory Muscle Training (IMT) on Breathing, Balance, and Blood Pressure Maintenance in Spinal Cord Injury (SCI)

TypeinterventionalSponsorUniversity of MiamiRan2019 to 2020Enrolled18ConditionsSpinal Cord InjuriesArmsInspiratory Muscle Training (IMT)
NCT07504055 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Transcutaneous Spinal Cord Stimulation on Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury

TypeinterventionalSponsorUniversity of LouisvilleRan2026 to 2029Enrolled40ConditionsSpinal Cord Injury, Orthostatic Hypertension, Autonomic DysreflexiaArmsSpinal Cord Transcutaneous Stimulation
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Sevda C AslanDepartment of Neurological Surgery, University of Louisville, Louisville, Kentucky.
David C RandallDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
Andrei V KrassioukovExperimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries (ICORD), Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada; GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Aaron PhillipsExperimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries (ICORD), Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada; GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Alexander V OvechkinDepartment of Neurological Surgery, University of Louisville, Louisville, Kentucky. Electronic address: alexander.ovechkin@louisville.edu.
GF Strong Rehabilitation Centre · CANeurological Surgery · USUniversity of Kentucky · USUniversity of Louisville · US

Funding

Mechanisms of plasticity and repair after SCIP30GM103507 · NIGMS · UNIVERSITY OF LOUISVILLE · PI WHITTEMORE, SCOTT R · 2012 to 2015
$4.2M
Respiratory motor control and blood pressure regulation after spinal cord injuryR01HL103750 · NHLBI · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2011 to 2014
$1.2M
NHLBI NIH HHS R01 HL103750NIGMS NIH HHS P30 GM103507
6 · The paper itself

Abstract

objectiveTo investigate the effects of respiratory motor training (RMT) on pulmonary function and orthostatic stress-mediated cardiovascular and autonomic responses in individuals with chronic spinal cord injury (SCI).

designBefore-after intervention case-controlled clinical study.

settingSCI research center and outpatient rehabilitation unit.

participantsA sample of (N=21) individuals with chronic SCI ranging from C3 to T2 diagnosed with orthostatic hypotension (OH) (n=11) and healthy, noninjured controls (n=10).

interventionsA total of 21±2 sessions of pressure threshold inspiratory-expiratory RMT performed 5d/wk during a 1-month period.

main outcome measuresStandard pulmonary function test: forced vital capacity, forced expiratory volume in one second, maximal inspiratory pressure, maximal expiratory pressure, beat-to-beat arterial blood pressure, heart rate, and respiratory rate were acquired during the orthostatic sit-up stress test before and after the RMT program.

resultsCompletion of RMT intervention abolished OH in 7 of 11 individuals. Forced vital capacity, low-frequency component of power spectral density of blood pressure and heart rate oscillations, baroreflex effectiveness, and cross-correlations between blood pressure, heart rate, and respiratory rate during the orthostatic challenge were significantly improved, approaching levels observed in noninjured individuals. These findings indicate increased sympathetic activation and baroreflex effectiveness in association with improved respiratory-cardiovascular interactions in response to the sudden decrease in blood pressure.

conclusionsRespiratory training increases respiratory capacity and improves orthostatic stress-mediated respiratory, cardiovascular, and autonomic responses, suggesting that this intervention can be an efficacious therapy for managing OH after SCI.

Indexed as

AdultAutonomic Nervous SystemBlood PressureBreathing ExercisesChronic DiseaseFemaleHeart RateHumansHypotension, OrthostaticMaleRespiratory Function TestsSpinal Cord InjuriesAutonomic nervous systemBlood pressureBreathing exercisesHypotension, orthostaticRehabilitationRespirationSpinal cord injuries

Identifiers

PMID26718236
PMCPMC4884550
OpenAlexW2212837891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.