ArticleJournal of clinical periodontology2016
Rescuing failed oral implants via Wnt activation.
Article in Journal of clinical periodontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions.Journal of functional biomaterials · 2025Review
- Signaling pathways of dental implants' osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways.BDJ open · 2024Review
- Topography-mediated immunomodulation in osseointegration; Ally or Enemy.Biomaterials · 2022Review
- Bone formation around unstable implants is enhanced by a WNT protein therapeutic in a preclinical in vivo model.Clinical oral implants research · 2020Article
- System for application of controlled forces on dental implants in rat maxillae: Influence of the number of load cycles on bone healing.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Effects of condensation and compressive strain on implant primary stability: A longitudinal, in vivo, multiscale study in mice.Bone & joint research · 2020Article
- A preclinical model links osseo-densification due to misfit and osseo-destruction due to stress/strain.Clinical oral implants research · 2019Article
- Development of a quantitative preclinical screening model for implant osseointegration in rat tail vertebra.Clinical oral investigations · 2019Article
- Enhancing osseointegration of titanium implants through large-grit sandblasting combined with micro-arc oxidation surface modification.Journal of materials science. Materials in medicine · 2019Article
- A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Mechanical and Biological Advantages of a Tri-Oval Implant Design.Journal of clinical medicine · 2019Article
- A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis.Journal of clinical medicine · 2019Article
- Biomechanics of Immediate Postextraction Implant Osseointegration.Journal of dental research · 2018Article
- Biophysical regulation of osteotomy healing: An animal study.Clinical implant dentistry and related research · 2017Article
- Relationships among Bone Quality, Implant Osseointegration, and Wnt Signaling.Journal of dental research · 2017Article
- Contribution of the PDL to Osteotomy Repair and Implant Osseointegration.Journal of dental research · 2017Article
- Effects of Condensation on Peri-implant Bone Density and Remodeling.Journal of dental research · 2017Article
- Promotion of natural tooth repair by small molecule GSK3 antagonists.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
aimImplant osseointegration is not always guaranteed and once fibrous encapsulation occurs clinicians have few options other than implant removal. Our goal was to test whether a WNT protein therapeutic could rescue such failed implants. MATERIAL AND
methodsTitanium implants were placed in over-sized murine oral osteotomies. A lack of primary stability was verified by mechanical testing. Interfacial strains were estimated by finite element modelling and histology coupled with histomorphometry confirmed the lack of peri-implant bone. After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated. Quantitative assays were employed to analyse the effects of L-WNT3A treatment.
resultsImplants in gap-type interfaces exhibited high interfacial strains and no primary stability. After verification of implant failure, L-WNT3A or L-PBS injections were initiated. L-WNT3A induced a rapid, significant increase in Wnt responsiveness in the peri-implant environment, cell proliferation and osteogenic protein expression. The amount of peri-implant bone and bone in contact with the implant were significantly higher in L-WNT3A cases.
conclusionsThese data demonstrate L-WNT3A can induce peri-implant bone formation even in cases where fibrous encapsulation predominates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.