ArticleJournal of neurogastroenterology and motility2016
Evaluation of Gastroesophageal Reflux Disease Using the Bravo Capsule pH System.
Article in Journal of neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05238636 (The Effect of Anti-reflux Procedures), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Anti-reflux Procedures (Stretta, LINX, and Fundoplication) on Physiological Parameters Contributing to Symptom Resolution in Adults With Gastro-oesophageal Reflux at a Single UK Tertiary Centre
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Diagnosis and treatment of patients with gastroesophageal reflux disease - a systematic review of cost-effectiveness and economic burden.BMC health services research · 2024Pooled it
- Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper.Alimentary pharmacology & therapeutics · 2020Trial
- Impact of prior endoscopic or surgical interventions on clinical outcomes after peroral endoscopic myotomy for achalasia.Surgical endoscopy · 2026Observational
- Laryngopharyngeal Reflux Prevalence and Predictors Among Doctors.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Isfahan Artificial Intelligence Event 2023: Reflux Detection Competition.Journal of medical signals and sensors · 2025Article
- Established and Novel Methods to Assess GERD: An Update.Visceral medicine · 2024Review
- pHoenix score: development and validation of a novel approach to decrease the number of inconclusive GERD diagnoses.Surgical endoscopy · 2024Observational
- Piloting an intraoral pH device to track gastroesophageal reflux in adults.Scientific reports · 2024Article
- Robotic Pills as Innovative Personalized Medicine Tools: A Mini Review.Recent advances in drug delivery and formulation · 2024Review
- Acute Chest Pain Following Bravo Device Placement.Cureus · 2023Article
- Continuous pH monitoring using a sensor for the early detection of anastomotic leaks.Frontiers in medical technology · 2023Article
- Evaluation of timed barium esophagram after per-oral endoscopic myotomy to predict clinical response.Endoscopy international open · 2021Article
- Review
- Esophageal pH Capsule Retention.ACG case reports journal · 2020Article
- Frequent Sips of the Water for the Management of Gastroesophageal Reflux Induced Refractory Cough: A Case Report and Review of the Literature.Case reports in gastrointestinal medicine · 2019Article
- Refractory Heartburn: A Challenging Problem in Clinical Practice.Digestive diseases and sciences · 2018Review
- Relationship Between Salivary Pepsin Concentration and Esophageal Mucosal Integrity in Patients With Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2017Article
- Large Buffering Effect of the Duodenal Bulb in Duodenal Switch: a Wireless pH-Metric Study.Obesity surgery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is a disease predominantly seen in the West but there is a rising trend in Asia. Ambulatory 24-hour catheter-based pH monitoring has been the de facto gold standard test for GERD that correlates symptoms with acid reflux episodes. However, drawbacks such as patients' discomfort, and catheter displacement render the test as cumbersome and error-prone. The Bravo pH wireless system is designed to be user-friendly and has an added advantage of prolonged pH monitoring. The system is comparable to the catheter-based pH monitoring system in terms of diagnostic yield and symptom-reflux association. Indications include evaluation of patients with refractory GERD symptoms and prior to anti-reflux surgery. Bravo utilizes a wireless pH-sensing capsule with a complete prepackaged system, and a data processing software. The capsule may be positioned indirectly using endoscopic or manometric landmarks or under direct endoscopic guidance. Optimal threshold cut-off values are yet to be standardized but based on available studies, for the Asian population, it may be recommended for total % time pH < 4 of 5.8 over 48 hours. Cost is a limitation but capsule placement is relatively safe although technical failures may be seen in small percentage of cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.