ArticleJournal of separation science2016
Two-step ion-exchange chromatographic purification combined with reversed-phase chromatography to isolate C-peptide for mass spectrometric analysis.
Article in Journal of separation science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- C-peptide as an important biomarker in diabetes management: The need for standardization of its measurement.Diabetes, obesity & metabolism · 2026Article
- MRM-based LC-MS method for accurate C-peptide quantitation.Journal of mass spectrometry and advances in the clinical lab · 2025Article
- Development and Validation of a Novel Isotope Dilution-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Serum C-Peptide.Annals of laboratory medicine · 2025Article
- Caspase-Based Fusion Protein Technology: Substrate Cleavability Described by Computational Modeling and Simulation.Journal of chemical information and modeling · 2024Article
- The potential for isotope dilution-LC-MS/MS to improve laboratory measurement of C-peptide: Reasons and critical determinants.Journal of mass spectrometry and advances in the clinical lab · 2021Article
- Development and Validation of a Novel LC-MS/MS Assay for C-Peptide in Human Serum.Journal of mass spectrometry and advances in the clinical lab · 2021Article
- Enhancing the promiscuity of a member of the Caspase protease family by rational design.Proteins · 2020Article
- Nanopore Event-Transduction Signal Stabilization for Wide pH Range under Extreme Chaotrope Conditions.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A liquid chromatography with mass spectrometry on-line platform that includes the orthogonal techniques of ion exchange and reversed phase chromatography is applied for C-peptide analysis. Additional improvement is achieved by the subsequent application of cation- and anion-exchange purification steps that allow for isolating components that have their isoelectric points in a narrow pH range before final reversed-phase mass spectrometry analysis. The utility of this approach for isolating fractions in the desired "pI window" for profiling complex mixtures is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.