Evidence map›Paper›PMID 26717246›Full record

ArticleBiomaterials2016

Thermally drawn fibers as nerve guidance scaffolds.

Ryan A Koppes, Seongjun Park, Tiffany Hood, Xiaoting Jia, Negin Abdolrahim Poorheravi, Anilkumar Harapanahalli Achyuta, Yoel Fink, Polina Anikeeva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  9. Sol-Gel-Derived Fibers Based on AmorphousMaterials (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Polymeric Fibers as Scaffolds for Spinal Cord Injury: A Systematic Review.Frontiers in bioengineering and biotechnology · 2021
    Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ryan A KoppesResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Seongjun ParkResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tiffany HoodDepartment of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xiaoting JiaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Negin Abdolrahim PoorheraviDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Anilkumar Harapanahalli AchyutaDraper Laboratory, 555 Technology Square, Cambridge, MA 02139, USA.
Yoel FinkResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Polina AnikeevaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: anikeeva@mit.edu.
Massachusetts Institute of Technology · USDraper Laboratory · USNortheastern University · US

Funding

Fiber Inspired Neural Probes for the Multifunctional Dynamic Brain MappingR01NS086804 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS086804NINDS NIH HHS R01 NS086804-01A1
6 · The paper itself

Abstract

Synthetic neural scaffolds hold promise to eventually replace nerve autografts for tissue repair following peripheral nerve injury. Despite substantial evidence for the influence of scaffold geometry and dimensions on the rate of axonal growth, systematic evaluation of these parameters remains a challenge due to limitations in materials processing. We have employed fiber drawing to engineer a wide spectrum of polymer-based neural scaffolds with varied geometries and core sizes. Using isolated whole dorsal root ganglia as an in vitro model system we have identified key features enhancing nerve growth within these fiber scaffolds. Our approach enabled straightforward integration of microscopic topography at the scale of nerve fascicles within the scaffold cores, which led to accelerated Schwann cell migration, as well as neurite growth and alignment. Our findings indicate that fiber drawing provides a scalable and versatile strategy for producing nerve guidance channels capable of controlling direction and accelerating the rate of axonal growth.

Indexed as

AnimalsAnimals, NewbornCell NucleusGanglia, SpinalGuided Tissue RegenerationMaterials TestingNerve RegenerationNeuritesPolymersRats, Sprague-DawleyTemperatureTissue ScaffoldsPolymersFiber drawingNeural scaffoldPeripheral nerve repairTissue engineering

Identifiers

PMID26717246
PMCPMC5134911
OpenAlexW2186510265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.