Evidence map›Paper›PMID 26716866›Full record

Trial reportEuropean journal of anaesthesiology2016

Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgery: A randomised double-blinded trial.

Su Hyun Lee, Namo Kim, Chang Yeong Lee, Min Gi Ban, Young Jun Oh

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of anaesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02962999 phase4completednot on this mapstarted 2017, after this paper: background citation

Effect Of Ketamine Infusion On Oxygenation And Ventilation Mechanics In Patients With Chronic Obstructive Pulmonary Disease Applied One Lung Ventilation

TypeinterventionalSponsorCukurova UniversityRan2017 to 2018Enrolled30ConditionsChronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe, LungcancerArmsKetamine, Saline
NCT06207331 naterminatednot on this mapstarted 2023, after this paper: background citation

Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorThe Second Affiliated Hospital of Chongqing Medical UniversityRan2023 to 2024Enrolled6ConditionsRespiratory Function Tests, Chronic Obstructive Pulmonary Disease, DexmedetomidineArmsDexmedetomidine 0.5 μg/kg, Dexmedetomidine 1 μg/kg, Saline
NCT07385898 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer

TypeinterventionalSponsorThe Second Affiliated Hospital of Chongqing Medical UniversityRan2023 to 2024Enrolled64ConditionsRectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, LaparoscopicArmsDexmedetomidine, Normal saline
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Su Hyun LeeFrom the Department of Anaesthesiology and Pain Medicine (SHL, NK, MGB, YJO), Anaesthesia and Pain Research Institute (SHL, NK, YJO), Department of Thoracic and Cardiovascular Surgery (CYL), Yonsei University College of Medicine, Seoul, Korea.
Namo Kim
Chang Yeong Lee
Min Gi Ban
Young Jun Oh
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a risk factor that increases the incidence of postoperative cardiopulmonary morbidity and mortality after lung resection. Dexmedetomidine, a selective α2-adrenoreceptor agonist, has been reported previously to attenuate intrapulmonary shunt during one-lung ventilation (OLV) and to alleviate bronchoconstriction.

objectiveThe objective is to determine whether dexmedetomidine improves oxygenation and lung mechanics in patients with moderate COPD during lung cancer surgery.

designA randomised, double-blinded, placebo-controlled study.

settingSingle university hospital.

participantsFifty patients scheduled for video-assisted thoracoscopic surgery who had moderate COPD. Patients were randomly allocated to a control group or a Dex group (n = 25 each).

interventionsIn the Dex group, dexmedetomidine was given as an initial loading dose of 1.0  μg  kg(-1) over 10  min followed by a maintenance dose of 0.5  μg  kg(-1)  h(-1) during OLV while the control group was administered a comparable volume of 0.9% saline. Data were measured at 30  min (DEX-30) and 60  min (DEX-60) after dexmedetomidine or saline administration during OLV.

main outcome measuresThe primary outcome was the effect of dexmedetomidine on oxygenation. The secondary outcome was the effect of dexmedetomidine administration on postoperative pulmonary complications.

resultsPatients in the Dex group had a significantly higher PaO2/FIO2 ratio (27.9 ± 5.8 vs. 22.5 ± 8.4 and 28.6 ± 5.9 vs. 21.0 ± 9.9 kPa, P < 0.05), significantly lower dead space ventilation (19.2 ± 8.5 vs. 24.1 ± 8.1 and 19.6 ± 6.7 vs. 25.3 ± 7.8%, P < 0.05) and higher dynamic compliance at DEX-30 and DEX-60 (P = 0.0001 and P = 0.0184) compared with the control group. In the Dex group, the PaO2/FIO2 ratio in the postoperative period was significantly higher (P = 0.022) and the incidence of ICU admission was lower than in the control group.

conclusionDexmedetomidine administration may provide clinically relevant benefits by improving oxygenation and lung mechanics in patients with moderate COPD undergoing lung cancer surgery.

trial registrationClinicalTrial.gov identifier: NCT 02185430.

Indexed as

PneumonectomyThoracic Surgery, Video-AssistedAdrenergic alpha-2 Receptor AgonistsAgedBronchodilator AgentsDexmedetomidineDouble-Blind MethodDrug Administration ScheduleFemaleHospitals, UniversityHumansLungLung NeoplasmsMaleMiddle AgedPulmonary Disease, Chronic ObstructiveAdrenergic alpha-2 Receptor AgonistsBronchodilator AgentsDexmedetomidine

Identifiers

PMID26716866
PMCPMC4780481
OpenAlexW2313972046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.