ArticlePloS one2015
Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 188 citations in OpenAlex.
- Low-Temperature Transcriptional Responses in Selected pESI-PositiveFoods (Basel, Switzerland) · 2026Article
- A Biological Approach to Antimicrobial Resistance in New and Old Bacterial Pathogens.Pathogens (Basel, Switzerland) · 2026Review
- One Health transmission of plasmid-mediated antimicrobial resistance: genomic insights at the interface of food, animals, humans and the environment.JAC-antimicrobial resistance · 2026Review
- Evolutionary dynamics of the multidrug-resistantMicrobial genomics · 2026Article
- Genomic characterization of antimicrobial resistance and virulence determinants inApplied and environmental microbiology · 2026Article
- Distinct ESBL dissemination mechanism associated with the hybrid transposon TnMicrobiology spectrum · 2026Article
- Development and validation of a quantitative method for the enumeration ofFrontiers in microbiology · 2026Article
- A rare case of gastroenteritis due toFrontiers in public health · 2026Article
- Influence of the Salmonella Infantis pESI plasmid on disinfectant efficacy when in biofilm.Access microbiology · 2026Article
- A spotlight on multidrug-resistantFrontiers in microbiology · 2026Review
- Molecular epidemiology of pESI-carryingEmerging microbes & infections · 2025Article
- Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.Emerging infectious diseases · 2025Article
- Harnessing probiotics and bacteriophages to fight Salmonella and limit the use of antibiotics in broilers: a study in commercial conditions.Poultry science · 2025Article
- Prevalence and Antimicrobial Resistance of Nontyphoidal Salmonella in Retail Meat in Puerto Rico: A Two-Year Study (2022-2023).Journal of food protection · 2025Article
- Surveillance ofPathogens (Basel, Switzerland) · 2025Article
- Emergence and characteristics of multidrug-resistantMicrobiology spectrum · 2025Article
- Prevalence of ESBL-Resistant Genes in Birds in Italy-A Comprehensive Review.Animals : an open access journal from MDPI · 2025Review
- Emergence and Clonal Spread of Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2025Article
- Determination of Antimicrobial Resistance Megaplasmid-Like pESI Structures Contributing to the Spread ofAntibiotics (Basel, Switzerland) · 2025Article
- Emerging Resistance and Virulence Patterns inAntibiotics (Basel, Switzerland) · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the spread of a clone of multidrug-resistant (MDR), ESBL-producing (blaCTX-M-1) Salmonella enterica subsp. enterica serovar Infantis, in the Italian broiler chicken industry and along the food-chain. This was first detected in Italy in 2011 and led to human infection in Italy in 2013-2014.A set (n = 49) of extended-spectrum cephalosporin (ESC)-resistant (R) isolates of S. Infantis (2011-2014) from humans, food-producing animals and meat thereof, were studied along with a selected set of earlier and more recent ESC-susceptible (ESC-S) isolates (n = 42, 2001-2014). They were characterized by macrorestriction-PFGE analysis and genetic environment of ESC-resistance. Isolates representative of PFGE-patterns and origin were submitted to Whole Genome Sequencing. The emerging ESC-R clone, detected mainly from broiler chickens, broiler meat and humans, showed a minimum pattern of clinical resistance to cefotaxime, tetracycline, sulfonamides, and trimethoprim, beside ciprofloxacin microbiological resistance (MIC 0.25 mg/L). All isolates of this clone harbored a conjugative megaplasmid (~ 280-320 Kb), similar to that described in ESC-susceptible S. Infantis in Israel (pESI-like) in 2014. This megaplasmid carried the ESBL gene blaCTX-M-1, and additional genes [tet(A), sul1, dfrA1 and dfrA14] mediating cefotaxime, tetracycline, sulfonamide, and trimethoprim resistance. It also contained genes conferring enhanced colonization capability, virulence (fimbriae, yersiniabactin), resistance and fitness (qacE1, mer) in the intensive-farming environment. This emerging clone of S. Infantis has been causing infections in humans, most likely through the broiler industry. Since S. Infantis is among major serovars causing human infections in Europe and is an emerging non-typhoidal Salmonella globally, further spread of this lineage in primary productions deserves quick and thorough risk-management strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.