ArticleOncotarget2016
Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer.European journal of human genetics : EJHG · 2025Article
- Comprehensive atlas of mitochondrial distribution and dynamics during oocyte maturation in mouse models.Biomarker research · 2024Article
- Systems genetics analysis of human body fat distribution genes identifies adipocyte processes.Life science alliance · 2024Article
- Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms.Pharmaceutical research · 2024Article
- Exome sequencing identifiesmedRxiv : the preprint server for health sciences · 2024Article
- Mitochondrial deoxyguanosine kinase is required for female fertility in mice.Acta biochimica et biophysica Sinica · 2024Article
- Noninvasive metabolic profiling of cumulus cells, oocytes, and embryos via fluorescence lifetime imaging microscopy: a mini-review.Human reproduction (Oxford, England) · 2023Review
- Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.Journal of the Endocrine Society · 2023Article
- The Role of PEDF in Reproductive Aging of the Ovary.International journal of molecular sciences · 2022Article
- Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.Nature communications · 2022Article
- Uncovering the important role of mitochondrial dynamics in oogenesis: impact on fertility and metabolic disorder transmission.Biophysical reviews · 2021Review
- Miga-mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis.eLife · 2020Article
- Single-Cell Transcriptomics of Human Oocytes: Environment-Driven Metabolic Competition and Compensatory Mechanisms During Oocyte Maturation.Antioxidants & redox signaling · 2019Article
- Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis.Experimental and therapeutic medicine · 2018Article
- Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation.Oncotarget · 2017Article
- Mitofusin-2 is required for mouse oocyte meiotic maturation.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial dynamics change mitochondrial morphological features and numbers as a part of adaptive cellular metabolism, which is vital for most eukaryotic cells and organisms. A disease or even death of an animal can occur if these dynamics are disrupted. Using large-scale genetic screening in fruit flies, we previously found the gene mitoguardin (Miga), which encodes a mitochondrial outer-membrane protein and promotes mitochondrial fusion. Knockout mouse strains were generated for the mammalian Miga homologs Miga1 and Miga2. Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile. Mitochondria became clustered in the cytoplasm of oocytes from the germinal-vesicle stage to meiosis II; production of reactive oxygen species increased in mitochondria and caused damage to mitochondrial ultrastructures. Additionally, reduced ATP production, a decreased mitochondrial-DNA copy number, and lower mitochondrial membrane potential were detected in Miga1/2-/- oocytes during meiotic maturation. These changes resulted in low rates of polar-body extrusion during oocyte maturation, reduced developmental potential of the resulting early embryos, and consequently female subfertility. We provide direct evidence that MIGA1/2-regulated mitochondrial dynamics is crucial for mitochondrial functions, ensure oocyte maturation, and maintain the developmental potential.
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