ArticleEndoscopy international open2015
Early clinical experience of the safety and efficacy of EndoClot in the management of non-variceal upper gastrointestinal bleeding.
Article in Endoscopy international open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Precise and optimal delivery techniques of hemostatic powders in gastrointestinal bleeding.Clinical endoscopy · 2026Review
- Unanticipated gastroduodenal fistula induced by multiple magnetic beads: successful endoscopic management without the need for surgery.Endoscopy · 2025Article
- Unsuspected efficacy of starch-based polysaccharideWorld journal of gastrointestinal endoscopy · 2025Article
- Efficacy and applications for PuraStatWorld journal of gastrointestinal endoscopy · 2025Article
- Non-variceal Upper Gastrointestinal Bleeding and Its Endoscopic Management.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Review
- Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review.World journal of gastroenterology · 2024Article
- [Non-Variceal Upper Gastrointestinal Bleeding].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- Turn over the new leaf of the treatment in peptic ulcer bleeding: a review of the literature.Therapeutic advances in gastroenterology · 2024Review
- Endoscopic Management of Bleeding in Altered Anatomy after Upper Gastrointestinal Surgery.Medicina (Kaunas, Lithuania) · 2023Review
- Topical hemostatic agents in the management of upper gastrointestinal bleeding: a meta-analysis.Endoscopy international open · 2023Article
- Hemostatic Powders in Non-Variceal Upper Gastrointestinal Bleeding: The Open Questions.Medicina (Kaunas, Lithuania) · 2023Review
- An update on the management of non-variceal upper gastrointestinal bleeding.Gastroenterology report · 2023Review
- Hemostatic powders for gastrointestinal bleeding: a review of old, new, and emerging agents in a rapidly advancing field.Endoscopy international open · 2022Review
- PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study.Surgical endoscopy · 2022Observational
- Hemostatic efficacy and safety of the hemostatic powder UI-EWD in patients with lower gastrointestinal bleeding.BMC gastroenterology · 2022Article
- Propensity score matching analysis to evaluate efficacy of polyethylene oxide adhesive on preventing delayed bleeding after gastric endoscopic submucosal dissection.Scientific reports · 2022Article
- Update on the management of upper gastrointestinal bleeding.BMJ medicine · 2022Review
- Endoscopic advances in the management of non-variceal upper gastrointestinal bleeding: A review.World journal of gastrointestinal endoscopy · 2020Review
- Management of Bleeding from Unresectable Gastric Cancer.Biomedicines · 2019Review
- Comparison of HemosprayWorld journal of gastroenterology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimsEndoClot is a novel topical hemostatic powder approved for use in non-variceal upper gastrointestinal bleeding. This study examines its impact as rescue therapy in the management of gastrointestinal bleeding for which standard endoscopic therapy failed to achieve hemostasis.
methodsThis observational study covered a 24-month period. Data were collated from patients treated with EndoClot for comparison with a cohort of patients managed with standard endoscopic therapy. End points of this study included immediate hemostasis, 30-day rebleed rate, 30-day mortality rate, and adverse events.
resultsBetween April 1, 2012, and March 31, 2014, gastroscopic procedures were performed in 1009 patients, of whom 173 required endoscopic therapy. EndoClot was used in 21 patients, with immediate hemostasis achieved in all cases, a 30-day rebleed rate of 4.8 % (95 % confidence interval [95 %CI] - 4.34 % to 3.94 %), and a 30-day mortality rate of 19.0 % (95 %CI 2.29 % - 35.91 %). Despite higher risk bleeds in this cohort of patients, Fisher's exact test demonstrated no significant difference between their 30-day mortality rate (P = 0.51) and rebleed rate (P = 0.31) and those of the patients treated with standard endoscopic hemostatic techniques.
conclusionsThis study demonstrates that EndoClot can be used both safely and effectively in the management of non-variceal upper gastrointestinal bleeding.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.