Evidence map›Paper›PMID 26716027›Full record

ArticleJournal of thoracic disease2015

Genetic variants of the class A scavenger receptor gene are associated with essential hypertension in Chinese.

Min Zhang, Zhijun Han, Zihe Yan, Qichen Cui, Yuhai Jiang, Mingzhu Gao, Wei Yu, Jun Hua, Hongyu Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Min Zhang1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Zhijun Han1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Zihe Yan1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Qichen Cui1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Yuhai Jiang1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Mingzhu Gao1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Wei Yu1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Jun Hua1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Hongyu Huang1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Wuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe class A scavenger receptor, which is encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with many cardiovascular events. However, whether it links genetically to essential hypertension (EH) in Chinese is not defined.

methodsWe performed an independent case-control study in a Chinese population consisting of 617 EH cases and 620 controls by genotyping three single nucleotide polymorphisms (SNPs) of MSR1.

resultsWe found that rs13306541 and rs3747531 were significantly associated with an increased risk of EH with per allele odds ratio (OR) of 1.63 [95% confidence interval (CI): 1.27-2.09; P<0.001] and 1.29 (95% CI: 1.09-1.52; P=0.003), respectively. Individuals with 2-4 risk alleles had a 2.03-fold (95% CI: 1.48-2.78) increased risk of EH compared with those having none of the risk alleles (P for trend <0.001).

conclusionsOur results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of EH in combination with traditional risk factors of EH in Chinese population.

Indexed as

Chinese populationClass A scavenger receptor geneessential hypertension (EH)single nucleotide polymorphisms (SNPs)

Identifiers

PMID26716027
PMCPMC4669284
OpenAlexW2173761498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.