ArticleEuropean journal of microbiology & immunology2015
The Role of Gelatinases in Campylobacter Jejuni Infection of Gnotobiotic Mice.
Article in European journal of microbiology & immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 38 citations in OpenAlex.
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- The Host-Specific Intestinal Microbiota Composition ImpactsPathogens (Basel, Switzerland) · 2020Article
- Inflammatory Immune Responses and Gut Microbiota Changes FollowingPathogens (Basel, Switzerland) · 2020Article
- Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following PeroralPathogens (Basel, Switzerland) · 2020Article
- Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model.Gut pathogens · 2020Article
- Murine fecal microbiota transplantation lowers gastrointestinal pathogen loads and dampens pro-inflammatory immune responses in Campylobacter jejuni infected secondary abiotic mice.Scientific reports · 2019Article
- Virulence of a T6SS Campylobacter jejuni chicken isolate from North Romania.BMC research notes · 2019Article
- Multidrug-ResistantFrontiers in immunology · 2019Article
- Protease Activity ofFrontiers in cellular and infection microbiology · 2019Article
- Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-DoseFrontiers in cellular and infection microbiology · 2019Article
- Immunopathological properties of theGut pathogens · 2019Article
- Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a ClinicalFrontiers in immunology · 2019Article
- Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses inFrontiers in immunology · 2019Article
- Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators inDiagnostics (Basel, Switzerland) · 2018Article
- Comparisons of gut microbiota profiles in wild-type and gelatinase B/matrix metalloproteinase-9-deficient mice in acute DSS-induced colitis.NPJ biofilms and microbiomes · 2018Article
- Multidrug-ResistantEuropean journal of microbiology & immunology · 2017Article
- Toll-Like Receptor-4 Dependent Inflammatory Responses Following Intestinal Colonization of Secondary Abiotic IL10-Deficient Mice with Multidrug-ResistantEuropean journal of microbiology & immunology · 2017Article
- Small Intestinal Pro-Inflammatory Immune Responses FollowingEuropean journal of microbiology & immunology · 2017Article
- Microbiota Composition and Immune Responses DuringEuropean journal of microbiology & immunology · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMP)-2 and -9 (also referred to gelatinases-A and -B, respectively) are upregulated in the inflamed gut of mice and men. We recently demonstrated that synthetic gelatinase blockage reduced large intestinal pro-inflammatory immune responses and apoptosis following murine Campylobacter (C.) jejuni infection. In order to address which gelatinase mediates C. jejuni-induced immune responses, gnotobiotic MMP-2(-/-), MMP-9(-/-), and wildtype (WT) mice were generated by broadspectrum antibiotic treatment and perorally infected with C. jejuni strain 81-176. The pathogen stably colonized the murine intestinal tract irrespective of the genotype but did not translocate to extra-intestinal compartments. At days 8 and 14 postinfection (p.i.), less pronounced colonic histopathological changes were observed in infected MMP-2(-/-) mice, less distinct epithelial apoptosis, but more epithelial proliferation in both MMP-2(-/-) and MMP-9(-/-) mice, as compared to WT controls. Reduced immune responses in gelatinase-deficient mice were characterized by lower numbers of effector as well as innate and adaptive immune cells within the colonic mucosa and lamina propria. The expression of IL-22, IL-18, IL-17A, and IL-1β mRNA was higher in the colon of MMP-2(-/-) as compared to WT mice. In conclusion, both MMP-2 and MMP-9 are differentially involved in mediating C. jejuni-induced intestinal immunopathology.
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