ArticleThe Malaysian journal of medical sciences : MJMS
Maternal Geophagy of Calabash Chalk on Foetal Cerebral Cortex Histomorphology.
Article in The Malaysian journal of medical sciences : MJMS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats.IBRO neuroscience reports · 2024Article
- Chemical analysis of calabash chalk and its effect on locomotor activities and behavior inHeliyon · 2023Article
- Effect of "edible clay" (takere) suspension on serum lipid profiles and atherogenic indices of normal Wistar rats.Food science & nutrition · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalabash chalk, a kaolin-base substance is a common geophagic material mostly consumed by pregnant women. This study investigated its effect on the histomorphology of the foetal cerebral cortex.
methodsTwelve gestating Wistar rats were divided equally into groups 1 and 2. On pregnancy day seven (PD7), group 2 animals were administered 200 mg/kg body weight of calabash chalk suspension, while group 1 animals served as the control and received 1 ml of distilled water, by oral gavages and for 14 days (PD7-PD20). On PD21, the dams were sacrificed, and the foetuses removed, examined for gross malformations, weighed and culled to two foetuses per mother. Their whole brains were excised, weighed and preserved using 10% buffered formalin, and routinely processed by haematoxylin and eosin, and Luxol fast blue methods.
resultsThe foetuses showed no morphological change, but their mean body weights was higher (p=0.0001). Histomorphological sections of the cerebral cortex showed hypertrophy and hyperplasia of cells in all the cortical layers, with less demonstrated Nissl and higher (p=0.001) cellular population compared with the control group.
conclusionCalabash chalk cause body weight increase and histomorphological changes in the cerebral cortex of foetuses.
Indexed as
Identifiers
26715904PMC4683845What OpenQuestion holds
Registered trials
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