ArticleThe Malaysian journal of medical sciences : MJMS
Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor-ß (TGF-ß) in Pregnant Mice Infected with Malaria.
Article in The Malaysian journal of medical sciences : MJMS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Biological Activity ofInternational journal of molecular sciences · 2026Article
- Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice.Infection and immunity · 2025Article
- Nontypeable Haemophilus influenzae challenge during gammaherpesvirus infection enhances viral reactivation and latency.Virology · 2024Article
- An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant.BMC infectious diseases · 2024Article
- Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically.Pathogens (Basel, Switzerland) · 2020Review
- Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA.Malaria journal · 2018Article
- IL-17 induces macrophages to M2-like phenotype via NF-κB.Cancer management and research · 2018Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring pregnancy, the balanced dominance of the T helper17 response shifts to a Th2 response that is characterised by the production of IL-10, following the completion of the implantation process. Transforming growth factor-β (TGF-β) expression is associated with the completion of trophoblast invasion and placental growth. This study assessed the effect of malaria infection on the levels of IL-17, IL-10, and TGF-β in the plasma of pregnant mice with malaria.
methodsSeventeen pregnant BALB/C mice were divided into two groups: mice infected with Plasmodium berghei (treatment group) and uninfected mice (control group). The mice were sacrificed on day 18 post-mating. Parasitemia was measured by Giemsa staining. The levels of IL-17, IL-10, and TGF-β were measured by ELISA.
resultsUsing independent t test, the IL-17 levels in the treatment group were higher than those in the control group (= = 0.040). The IL-10 levels in the treatment group were lower than those in the control group (= = 0.00). There was no significant difference in the TGF-β levels (= = 0.055) between two groups. However, using SEM analysis the degree of parasitemia decreased the plasma TGF-β levels (tcount = 5.148; ≥ ttable = 1.96). SEM analysis showed that a high degree of parasitemia increased the IL-17 levels and decreased the IL-10 and TGF-β levels.
conclusionMalaria infection during pregnancy interferes with the systemic balance by increasing the IL-17 levels and decreasing the IL-10 and TGF-β levels.
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Identifiers
26715893PMC4681718W2460132622What OpenQuestion holds
Registered trials
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