Evidence map›Paper›PMID 26715848›Full record

ArticleNeuropsychiatric disease and treatment2015

Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study.

Yi Shao, Feng-Qin Cai, Yu-Lin Zhong, Xin Huang, Ying Zhang, Pei-Hong Hu, Chong-Gang Pei, Fu-Qing Zhou, Xian-Jun Zeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yi ShaoDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Feng-Qin CaiDepartment of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Yu-Lin ZhongDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Xin HuangDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China ; Department of Ophthalmology, First People's Hospital of Jiujiang, Jiujiang, People's Republic of China.
Ying ZhangDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Pei-Hong HuDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Chong-Gang PeiDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Fu-Qing ZhouDepartment of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Xian-Jun ZengDepartment of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
First Affiliated Hospital of Nanchang University · CNJiujiang First People's Hospital · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the underlying regional homogeneity (ReHo) in brain-activity deficit in patients with optic neuritis (ON) and its relationship with behavioral performance. MATERIALS AND

methodsIn total, twelve patients with ON (four males and eight females) and twelve (four males and eight females) age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess the local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the visual evoked potential (VEP) in patients with ON.

resultsCompared with the healthy controls, patients with ON showed lower ReHo in the left cerebellum, posterior lobe, left middle temporal gyrus, right insula, right superior temporal gyrus, left middle frontal gyrus, bilateral anterior cingulate cortex, left superior frontal gyrus, right superior frontal gyrus, and right precentral gyrus, and higher ReHo in the cluster of the left fusiform gyrus and right inferior parietal lobule. Meanwhile, we found that the VEP amplitude of the right eye in patients with ON showed a positive correlation with the ReHo signal value of the left cerebellum posterior lobe (r=0.701, P=0.011), the right superior frontal gyrus (r=0.731, P=0.007), and the left fusiform gyrus (r=0.644, P=0.024). We also found that the VEP latency of the right eye in ON showed a positive correlation with the ReHo signal value of the right insula (r=0.595, P=0.041).

conclusionON may involve dysfunction in the default-mode network, which may reflect the underlying pathologic mechanism.

Indexed as

optic neuritisregional homogeneityrs-fMRIvisual evoked potential

Identifiers

PMID26715848
PMCPMC4686319
OpenAlexW2211011025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.