SynthesisArchives of disease in childhood2016
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
Synthesis in Archives of disease in childhood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Efficacy of Racecadotril in acute diarrhea in children: systematic review of double blind randomized clinical trials.European journal of clinical pharmacology · 2026Pooled it
- Racecadotril for acute diarrhoea in children.The Cochrane database of systematic reviews · 2019Pooled it
- Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.BMC pediatrics · 2018Pooled it
- Pooled it
- Prevalence and Etiology of Diarrhea in Children Under 5 Years Old at the Ngaoundere Regional Hospital, Cameroon: A Cross-Sectional Study.Health science reports · 2025Article
- Racecadotril in the management of diarrhea: an underestimated therapeutic option?Therapeutic advances in gastroenterology · 2025Review
- Review
- Intestinal secretory mechanisms and diarrhea.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Treading a HOSTile path: Mapping the dynamic landscape of host cell-rotavirus interactions to explore novel host-directed curative dimensions.Virulence · 2021Review
- Molecular epidemiology of rotavirus A and adenovirus among children with acute diarrhea in Hangzhou, China.Gut pathogens · 2020Article
- Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia.ClinicoEconomics and outcomes research : CEOR · 2018Article
- Rotavirus infection.Nature reviews. Disease primers · 2017Review
- Probiotics in Children: What Is the Evidence?Pediatric gastroenterology, hepatology & nutrition · 2017Review
- Antidiarrheal Drug Therapy.Current gastroenterology reports · 2017Review
- Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs (Comparative medicine · 2017Article
- The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand.ClinicoEconomics and outcomes research : CEOR · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRacecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea without affecting intestinal motility. An up-to-date systematic review is indicated to summarise the evidence on racecadotril for the treatment of acute diarrhoea in children.
designA Cochrane format systematic review of randomised controlled trials (RCTs). Data extraction and assessment of methodological quality were performed independently by two reviewers. Methodological quality was assessed using the Cochrane risk of bias tool. PATIENTS: Children with acute diarrhoea, as defined by the primary studies.
interventionsRCTs comparing racecadotril with placebo or other interventions. MAIN OUTCOME MEASURS: Duration of illness, stool output/volume and adverse events.
resultsSeven RCTs were included, five comparing racecadotril with placebo or no intervention, one with pectin/kaolin and one with loperamide. Moderate to high risk of bias was present in all studies. There was no significant difference in efficacy or adverse events between racecadotril and loperamide. A meta-analysis of three studies with 642 participants showed significantly shorter duration of symptoms with racecadotril compared with placebo (mean difference -53.48 h, 95% CI -65.64 to -41.33). A meta-analysis of five studies with 949 participants showed no significant difference in adverse events between racecadotril and placebo (risk ratio 0.99, 95% CI 0.73 to 1.34).
conclusionsThere is some evidence that racecadotril is more effective than placebo or no intervention in reducing the duration of illness and stool output in children with acute diarrhoea. However, the overall quality of the evidence is limited due to sparse data, heterogeneity and risk of bias. Racecadotril appears to be safe and well tolerated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.