ArticleGenetics2016
Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Naturally Occurring Variability in the Regulatory Region of theInternational journal of molecular sciences · 2026Article
- Leveraging low-cost short-read sequencing: revolutionizing complex trait genetics.Molecular biology and evolution · 2026Article
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
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- Genetic Architecture Underlying Response to the Fungal PathogenEvolutionary applications · 2025Article
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- Genomic architecture of phenotypic extremes in a wild cervid.BMC genomics · 2022Article
- Genomic basis for drought resistance in European beech forests threatened by climate change.eLife · 2021Article
- Many ways to make darker flies: Intra- and interspecific variation inEcology and evolution · 2021Article
- Genetic architecture of a body colour cline in Drosophila americana.Molecular ecology · 2020Article
- Shared genetic susceptibilities for irritable bowel syndrome and depressive disorder in Chinese patients uncovered by pooled whole-exome sequencing.Journal of advanced research · 2020Article
- Pleiotropic Effects ofFrontiers in physiology · 2019Article
- bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.PLoS genetics · 2018Article
- Pleiotropic effects of regulatory variation in tan result in correlation of two pigmentation traits in Drosophila melanogaster.Molecular ecology · 2018Article
- Genomics of coloration in natural animal populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Strong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results.Genome biology · 2017Article
- Article
- Article
- Ancestral population reconstitution from isofemale lines as a tool for experimental evolution.Ecology and evolution · 2016Article
- The Genetic Basis of Pigmentation Differences Within and Between Drosophila Species.Current topics in developmental biology · 2016Review
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4 authors.
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Abstract
The degree of concordance between populations in the genetic architecture of a given trait is an important issue in medical and evolutionary genetics. Here, we address this problem, using a replicated pooled genome-wide association study approach (Pool-GWAS) to compare the genetic basis of variation in abdominal pigmentation in female European and South African Drosophila melanogaster. We find that, in both the European and the South African flies, variants near the tan and bric-à-brac 1 (bab1) genes are most strongly associated with pigmentation. However, the relative contribution of these loci differs: in the European populations, tan outranks bab1, while the converse is true for the South African flies. Using simulations, we show that this result can be explained parsimoniously, without invoking different causal variants between the populations, by a combination of frequency differences between the two populations and dominance for the causal alleles at the bab1 locus. Our results demonstrate the power of cost-effective, replicated Pool-GWAS to shed light on differences in the genetic architecture of a given trait between populations.
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