ArticleMolecular biology and evolution2016
Laterally Transferred Gene Recruited as a Venom in Parasitoid Wasps.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 63 citations in OpenAlex.
- A compendium of horizontal gene transfers in Metazoa.Scientific data · 2026Article
- The eukaryotic horizontal gene transfer dataset a compendium.bioRxiv : the preprint server for biology · 2025Article
- Genome-Wide Identification and Expression Analysis of the GH19 Chitinase Gene Family in Sea Island Cotton.Current issues in molecular biology · 2025Article
- Multi-omic approach to characterize the venom of the parasitic wasp Cotesia congregata (Hymenoptera: Braconidae).BMC genomics · 2025Article
- Host and venom evolution in parasitoid wasps: does independently adapting to the same host shape the evolution of the venom gland transcriptome?BMC biology · 2024Article
- Histone Acetylation Enhancing Host Melanization in Response to Parasitism by an Endoparasitoid Wasp.Insects · 2024Article
- Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis.Molecular biology and evolution · 2023Article
- An Overview of Ovarian Calyx Fluid Proteins ofBiomolecules · 2023Article
- A serpin gene from a parasitoid wasp disrupts host immunity and exhibits adaptive alternative splicing.PLoS pathogens · 2023Article
- Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity.Genome research · 2023Article
- Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Biocatalytic potential ofiScience · 2023Article
- Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology.Frontiers in bioengineering and biotechnology · 2023Review
- Rapid Genomic Evolution Drives the Diversification of Male Reproductive Genes in Dung Beetles.Genome biology and evolution · 2021Article
- Genome of the pincer wasp Gonatopus flavifemur reveals unique venom evolution and a dual adaptation to parasitism and predation.BMC biology · 2021Article
- Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer.Nature communications · 2021Article
- Two novel venom proteins underlie divergent parasitic strategies between a generalist and a specialist parasite.Nature communications · 2021Article
- Venomics of the ectoparasitoid wasp Bracon nigricans.BMC genomics · 2020Article
- Horizontal transfer of a natterin-like toxin encoding gene within the holobiont of the reef building coralJournal of venom research · 2020Article
- Evaluating the evolution and function of the dynamic Venom Y protein in ectoparasitoid wasps.Insect molecular biology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Parasitoid wasps use venom to manipulate the immunity and metabolism of their host insects in a variety of ways to provide resources for their offspring. Yet, how genes are recruited and evolve to perform venom functions remain open questions. A recently recognized source of eukaryotic genome innovation is lateral gene transfer (LGT). Glycoside hydrolase family 19 (GH19) chitinases are widespread in bacteria, microsporidia, and plants where they are used in nutrient acquisition or defense, but have previously not been known in metazoans. In this study, a GH19 chitinase LGT is described from the unicellular microsporidia/Rozella clade into parasitoid wasps of the superfamily Chalcidoidea, where it has become recruited as a venom protein. The GH19 chitinase is present in 15 species of chalcidoid wasps representing four families, and phylogenetic analysis indicates that it was laterally transferred near or before the origin of Chalcidoidea (∼95 Ma). The GH19 chitinase gene is highly expressed in the venom gland of at least seven species, indicating a role in the complex host manipulations performed by parasitoid wasp venom. RNAi knockdown in the model parasitoid Nasonia vitripennis reveals that-following envenomation-the GH19 chitinase induces fly hosts to upregulate genes involved in an immune response to fungi. A second, independent LGT of GH19 chitinase from microsporidia into mosquitoes was also found, also supported by phylogenetic reconstructions. Besides these two LGT events, GH19 chitinase is not found in any other sequenced animal genome, or in any fungi outside the microsporidia/Rozella clade.
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