ArticleEnvironmental health : a global access science source2015
Differential association of lead on length by zinc status in two-year old Mexican children.
Article in Environmental health : a global access science source, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Investigating zinc's role in mitigating blood lead levels' toxicity on gut microbiota diversity: NHANES 2007-2010.Toxicology letters · 2025Article
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City.Biological trace element research · 2023Article
- Is adiposity related to repeat measures of blood leukocyte DNA methylation across childhood and adolescence?Clinical obesity · 2023Article
- Lead Exposure Can Affect Early Childhood Development and Could Be Aggravated by Stunted Growth: Perspectives from Mexico.International journal of environmental research and public health · 2023Article
- Zinc status in public health: exploring emerging research trends through bibliometric analysis of the historical context from 1978 to 2022.Environmental science and pollution research international · 2023Review
- The Association of Children's Blood Lead Levels and Prevalence of Stunting in Tin Mining Area in Indonesia.Annals of global health · 2023Article
- Heavy metal blood concentrations in association with sociocultural characteristics, anthropometry and anemia among Kenyan adolescents.International journal of environmental health research · 2022Article
- Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.Medicine and science in sports and exercise · 2020Article
- Environmental exposure to metal mixtures and linear growth in healthy Ugandan children.PloS one · 2020Article
- Article
- Dietary exposures, epigenetics and pubertal tempo.Environmental epigenetics · 2019Article
- Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression.Epigenetics · 2018Article
- Protective Effects of Dietary Supplements Containing Probiotics, Micronutrients, and Plant Extracts Against Lead Toxicity in Mice.Frontiers in microbiology · 2018Article
- Article
- Peripubertal blood lead levels and growth among Russian boys.Environment international · 2017Article
- The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort.Environmental research · 2017Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundBlood lead levels have decreased in Mexico since leaded fuel was banned in 1997, but other sources remain, including the use of lead-glazed ceramics for food storage and preparation. Zinc deficiency is present in almost 30% of children aged 1-2 years. Previous studies have documented negative associations of both lead exposure and zinc deficiency with stature, but have not considered the joint effects. Given that the prevalence of stunting in pre-school aged children was 13.6% in 2012, the aim of this study was to evaluate if the relationship between blood lead and child stature was modified by zinc status.
methodsAnthropometry, dietary energy intake, serum zinc and blood lead were measured in 291 children aged 24 months from an ongoing birth cohort study in Mexico City. Child stature was represented by recumbent length as appropriate for this age group. The association between blood lead (BPb) and length-for-age Z score (LAZ) was evaluated using a model stratified by zinc status measured by standard criteria and adjusted for: birth length, breastfeeding practices, energy intake, maternal height and education.
resultsMedian (IQR) BPb was: 0.17 (0.12-0.26) μmol/L and 17% of the sample had zinc deficiency (<9.9 μmol/L). BPb was inversely associated with LAZ in the overall sample (β = -0.19, p = 0.02). In stratified models, this negative association was more than three times higher and statistically significant only in the zinc deficient group (β = -0.43, p = 0.04) compared to the zinc replete group (β = -0.12, p = 0.22) (BPb*zinc status, p-for-interaction = 0.04).
conclusionsZinc adequacy is a key factor that may attenuate the negative association of lead on stature in young children.
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