Trial reportEuropean journal of nutrition2017
The efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trial.
Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Effect of postpartum anaemia on maternal health-related quality of life: a systematic review and meta-analysis.BMC public health · 2022Pooled it
- The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.Scientific reports · 2020Trial
- Nutritional status of iron and vitamin D in postpartum women in northern Taiwan.Frontiers in nutrition · 2025Article
- Wellbeing Forecasting in Postpartum Anemia Patients.Healthcare (Basel, Switzerland) · 2023Article
- Gestational anemia and maternal antenatal and postpartum psychological distress in a prospective FinnBrain Birth Cohort Study.BMC pregnancy and childbirth · 2022Article
- Gestational iron supplementation reverses depressive-like behavior in post-partum Sprague Dawley rats: Evidence from behavioral and neurohistological studies.IBRO neuroscience reports · 2022Article
- Is iron deficiency a risk factor for postpartum depression? A case-control study in the Gaza Strip, Palestine.Public health nutrition · 2022Article
- The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia.Medicina (Kaunas, Lithuania) · 2022Article
- The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective.Nutrients · 2022Review
- Iron, neuro-bioavailability and depression.EJHaem · 2022Review
- The effectiveness of iron supplementation for postpartum depression: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- The contribution of iron deficiency to the risk of peripartum transfusion: a retrospective case control study.BMC pregnancy and childbirth · 2020Article
- Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity.Frontiers in human neuroscience · 2017Article
- Recent advances in understanding maternal perinatal mood disorders.F1000Research · 2017Review
- Anemia, Depression, and Suicidal Attempts in Women: Is There a Relationship?Journal of research in pharmacy practiceArticle
Corrections and comments
- Retraction · 2022-09-23Error in Methods · Lack of IRB/IACUC Approval and/or Compliance · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEvaluating early iron supplementation in non-anemic mothers with postpartum depression (PPD).
methodsThis randomized, double-blind, placebo-controlled trial evaluated 70 mothers with PPD. One week after delivery, the mothers were randomly allocated in the iron-treated (50 mg elemental iron/daily) and placebo-treated groups. After 6 weeks, the improvement of PPD symptoms was compared between the groups.
resultsFerritin significantly increased in the iron-treated group (p < 0.001), but not in the placebo group (p = 0.09). After intervention, ferritin was higher in the iron-treated group (medians: 78.2 vs. 37 mg/dl, p = 0.01). The rate of iron deficiency significantly decreased in the iron-treated group (p = 0.009), but not in the placebo group (p = 0.4). After intervention, the rate of iron deficiency was higher in the placebo group (31.4 vs. 8.5 %, p = 0.01). The Edinburgh Postnatal Depression Scale (EPDS) score significantly decreased in the iron-treated group (p < 0.001), but not in the placebo group (p = 0.13). After intervention, the EPDS score was lower in the iron-treated group (medians 9 vs. 12, p = 0.01). The improvement rate for PPD was significantly higher in the iron-treated group (42.8 vs. 20 %, p = 0.03). After intervention, mothers with continued PPD had lower ferritin than the improved mothers (41.8 vs. 67 mg/dl, p = 0.03). Mothers with continued depression had higher rate of iron deficiency compared to the improved mothers (27.1 vs. 4.5 %, p = 0.02).
conclusionsEarly iron supplementation in mothers with PPD significantly improves the iron stores and causes a significant improvement in PPD with a 42.8 % improvement rate during 6 weeks. Continued PPD might be related to the lower postpartum ferritin levels in untreated mothers.
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