Evidence map›Paper›PMID 26715509›Full record

ArticleThe Journal of membrane biology2016

Stimulation of Na(+),K(+)-ATPase Activity as a Possible Driving Force in Cholesterol Evolution.

Nicholas Lambropoulos, Alvaro Garcia, Ronald J Clarke

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The NaBiophysical reviews · 2023
    Review
  3. Review
  4. Review
  5. Cholesterol depletion inhibits NaThe Journal of biological chemistry · 2019
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas LambropoulosSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Alvaro GarciaSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia.
Ronald J ClarkeSchool of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia. ronald.clarke@sydney.edu.au.
University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol is exclusively produced by animals and is present in the plasma membrane of all animal cells. In contrast, the membranes of fungi and plants contain other sterols. To explain the exclusive preference of animal cells for cholesterol, we propose that cholesterol may have evolved to optimize the activity of a crucial protein found in the plasma membrane of all multicellular animals, namely the Na(+),K(+)-ATPase. To test this hypothesis, mirror tree and phylogenetic distribution analyses have been conducted of the Na(+),K(+)-ATPase and 3β-hydroxysterol Δ(24)-reductase (DHCR24), the last enzyme in the Bloch cholesterol biosynthetic pathway. The results obtained support the hypothesis of a co-evolution of the Na(+),K(+)-ATPase and DHCR24. The evolutionary correlation between DHCR24 and the Na(+),K(+)-ATPase was found to be stronger than between DHCR24 and any other membrane protein investigated. The results obtained, thus, also support the hypothesis that cholesterol evolved together with the Na(+),K(+)-ATPase in multicellular animals to support Na(+),K(+)-ATPase activity.

Indexed as

Biological EvolutionCell MembraneCholesterolCytochromes cMembrane ProteinsOxidoreductases Acting on CH-CH Group DonorsPhylogenySodium-Potassium-Exchanging ATPaseSqualene MonooxygenaseCholesterolCytochromes cMembrane ProteinsOxidoreductases Acting on CH-CH Group DonorsSodium-Potassium-Exchanging ATPaseSqualene Monooxygenase3β-Hydroxysterol Δ24-reductaseEukaryoteMirror tree analysisPlasma membraneSodium pumpSqualene monooxygenase

Identifiers

PMID26715509
OpenAlexW2215969351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.