Evidence map›Paper›PMID 26715466›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2016

The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease.

Gretchen O Reynolds, Michael W Otto, Terry D Ellis, Alice Cronin-Golomb

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04012086 nacompletednot on this map

Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled40ConditionsParkinson Disease, Cognitive ImpairmentArmsPhysical therapy
NCT04665869 nacompletednot on this mapstarted 2020, after this paper: background citation

Long-term Effects of Combined Balance and Brisk Walking on Alleviating Motor and Non-motor Symptoms in Parkinson's Disease: a Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2020 to 2022Enrolled100ConditionsParkinson DiseaseArmsCombined balance and brisk walking training, Flexibility and strengthening exercise
NCT06246747 nacompletednot on this mapstarted 2020, after this paper: background citation

The Use of Telerehabilitation to Improve Movement-related Outcomes and Quality of Life for Patients With Parkinson's Disease: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorWizecareRan2020 to 2023Enrolled19ConditionsParkinson DiseaseArmsIn clinic physical therapy, Telerehabilitation only
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effects of physical activity on sleep problems in breast cancer survivors: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  13. Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gretchen O ReynoldsBoston University, Department of Psychological and Brain Sciences, Boston, Massachusetts, USA.
Michael W OttoBoston University, Department of Psychological and Brain Sciences, Boston, Massachusetts, USA.
Terry D EllisBoston University, College of Health and Rehabilitation Sciences: Sargent College, Department of Physical Therapy & Athletic Training and Center for Neurorehabilitation, Boston, Massachusetts, USA.
Alice Cronin-GolombBoston University, Department of Psychological and Brain Sciences, Boston, Massachusetts, USA.

Funding

Enhancing Panic and Smoking Reduction Treatment with D-CycloserineR34DA034658 · NIDA · UNIVERSITY OF TEXAS AT AUSTIN · PI OTTO, MICHAEL W., SMITS, JASPER · 2013 to 2015
$622k
Improving Therapeutic Learning in Depression: Proof of ConceptR21MH102646 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI OTTO, MICHAEL W. · 2014 to 2015
$452k
A Cognitive-Behavioral Intervention for Anxiety in Parkinson's DiseaseF31MH102961 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REYNOLDS, GRETCHEN OLSON · 2013 to 2015
$99k
A Telemedicine Intervention to Improve Cognitive Function in Patients with PDI01RX001696 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SPARROW, DAVID W. · 2015 to 2017
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NIDA NIH HHS R34 DA034658NIMH NIH HHS F31 MH102961NIMH NIH HHS F31MH102961NIMH NIH HHS R21 MH102646RRD VA I01 RX001696
6 · The paper itself

Abstract

In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence-based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of nonmotor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include nonmotor outcomes in exercise trials with the goal of developing evidence-based exercise interventions as a safe, broad-spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.

Indexed as

Cognition DisordersExercise TherapyHumansMood DisordersParkinson DiseasecognitionexercisemoodParkinson's diseasesleep

Identifiers

PMID26715466
PMCPMC4724300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.