ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 7 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 7 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Pooled it
- A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2018Pooled it
- Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI.Neuroscience and biobehavioral reviews · 2017Pooled it
- Gender-related difference in altered fractional amplitude of low-frequency fluctuations after electroacupuncture on primary insomnia patients: A resting-state fMRI study.Brain and behavior · 2021Trial
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Trial
- Abnormal Intrinsic Functional Hubs in Severe Male Obstructive Sleep Apnea: Evidence from a Voxel-Wise Degree Centrality Analysis.PloS one · 2016Trial
- Insomnia and women: exploring vulnerability, impact, and intervention.Sleep & breathing = Schlaf & Atmung · 2026Review
- Task-induced hyperfunction of the left dorsolateral prefrontal cortex in patients with primary insomnia: a near-infrared spectroscopy study during a verbal fluency task.Frontiers in psychiatry · 2026Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.Brain imaging and behavior · 2025Observational
- Altered connection properties of the left dorsolateral superior frontal gyrus inFrontiers in neuroscience · 2025Article
- Cerebellar-limbic dysregulation and sensorimotor network alterations in male primary insomnia: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2025Article
- The enhancement of nodal properties in the dorsal visual pathway is associated with compensatory mechanisms of visuospatial cognitive abilities following total sleep deprivation.Frontiers in neuroscience · 2025Article
- Static and temporal dynamic alterations of local functional connectivity in chronic insomnia.Brain imaging and behavior · 2024Article
- Increased functional connectivity within the salience network in patients with insomnia.Sleep & breathing = Schlaf & Atmung · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences.
methodsForty-two PCPIs (27 females, 15 males) and 42 good sleepers (GSs; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. Amplitude of low frequency fluctuation (ALFF) method was used to assess the local brain features. The mean signal values of the different ALFF areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas.
resultsBoth female and male PCPIs showed higher ALFF in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower ALFF in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower ALFF in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher ALFF in the bilateral middle temporal gyrus and lower ALFF in the left limbic lobe. The different areas showed high test-retest stability (Clusters of contiguous volumes ≥ 1080 mm(3) with an intraclass correlation coefficient ≥ 0.80) and high degree of sensitivity and specificity.
conclusionsFemale PCPIs showed more regional brain differences with higher and lower ALFF responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.