Evidence map›Paper›PMID 26715231›Full record

ArticleSleep2016

Insomnia and Telomere Length in Older Adults.

Judith E Carroll, Stephanie Esquivel, Alyssa Goldberg, Teresa E Seeman, Rita B Effros, Jeffrey Dock, Richard Olmstead, Elizabeth C Breen, Michael R Irwin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 83 citations in OpenAlex.

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  15. The impact of insomnia on frailty and the hallmarks of aging.Aging clinical and experimental research · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Changes in telomere length and serum neurofilament light chain levels in female patients with chronic insomnia disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Judith E CarrollUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
Stephanie EsquivelUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
Alyssa GoldbergUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
Teresa E SeemanUniversity of California, Los Angeles, Department of Medicine, Division of Geriatrics, David Geffen School of Medicine, Los Angeles, CA.
Rita B EffrosUniversity of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA.
Jeffrey DockUniversity of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA.
Richard OlmsteadUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
Elizabeth C BreenUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
Michael R IrwinUniversity of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA.
University of California, Los Angeles · USChildren's National · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
The mucosal immune system: effects of aging and chronic antigenic stimulationR01AG032422 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFFROS, RITA BRICKMAN · 2009 to 2013
$5.0M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
Late life sleep disturbances: Effects on cell stress, telomerase, inflammationK01AG044462 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E · 2013 to 2017
$633k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NIA NIH HHS AG028748NIA NIH HHS K01 AG044462NIA NIH HHS K01AG044462NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01AG032422NIA NIH HHS R01 AG034588NIA NIH HHS R01-AG034588NIMH NIH HHS T32 MH019925
6 · The paper itself

Abstract

STUDY

objectivesInsomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging.

methodsA total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology.

resultsIn the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44.

conclusionsInsomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.

Indexed as

AgedAged, 80 and overAgingCase-Control StudiesCellular SenescenceChronic DiseaseFemaleHumansLeukocytes, MononuclearMaleMiddle AgedReal-Time Polymerase Chain ReactionRiskSleep Initiation and Maintenance DisordersTelomereagingcellular aginginsomnialate lifeolder adultssleeptelomere

Identifiers

PMID26715231
PMCPMC4763369
OpenAlexW2315258249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.