ArticleSleep2016
Airway Resistance in Children with Obstructive Sleep Apnea Syndrome.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Orthodontic Perspectives in the Interdisciplinary Management of Pediatric Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2025Review
- Detection of Simulated Pediatric Breathing by CPAP/Noninvasive Ventilation Devices.Respiratory care · 2023Article
- Home Respiratory Polygraphy and Spirometry in Normal Weight and Children with Obesity Suspected for Obstructive Sleep Apnea Syndrome: Are There Any Associations?Pulmonary medicine · 2023Article
- Critical to Know Pcrit: A Review on Pharyngeal Critical Closing Pressure in Obstructive Sleep Apnea.Frontiers in neurology · 2022Review
- Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Sleep-Disordered Breathing in Children with Recurrent Wheeze/Asthma: A Single Centre Study.Children (Basel, Switzerland) · 2017Article
- Effect of Obstructive Sleep Apnea Treatment on Lipids in Obese Children.Children (Basel, Switzerland) · 2017Article
- Individualized therapy for treating obstructive sleep apnea in pediatric Crouzon syndrome patients.Sleep & breathing = Schlaf & Atmung · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesEnlarged tonsils and adenoids, the main cause of obstructive sleep apnea syndrome (OSAS) in children, results in upper airway (UA) loading. This contributes to the imbalance between structural and neuromotor factors ultimately leading to UA collapse during sleep. However, it is unknown whether this UA loading can cause elevated airway resistance (AR) during wakefulness. We hypothesized that children with OSAS have elevated AR compared to controls and that this improves after OSAS treatment.
methodsCase control study performed at an academic hospital. Children with OSAS and nonsnoring healthy controls underwent baseline polysomnography and spirometry, and AR measurement by body plethysmography while breathing via an orofacial mask. Children with OSAS repeated the previously mentioned tests after adenotonsillectomy.
results31 OSAS participants (mean age ± SD = 9.7 ± 3.0 y, obstructive apnea-hypopnea index (OAHI) median [range] = 14.9 [2-58.7] events/h, body mass index [BMI] z = 1.5 ± 1) and 31 controls (age = 10.5 ± 2.5 y, P = 0.24; OAHI = 0.4 [0-1.4], P < 0.001; BMI z = 0.9 ± 1, P = 0.01) were tested. OSAS AR at baseline was 3.9 [1.5-10.3] cmH2O/L/sec and controls 2.8 [1.4 - 6.2] (P = 0.027). Both groups had similar spirometry results. 20 patients with OSAS were tested 6.4 ± 6.6 mo after adenotonsillectomy. OAHI decreased from 15.2 [2.1-58.7] to 0.5 [0 - 5.1] events/h postoperatively (P < 0.001), and AR decreased from 4.3 [1.5 - 10.3] to 2.8 [1.7 - 4.7] cmH2O/L/sec (P = 0.009).
conclusionsChildren with OSAS have elevated AR that decreases after treatment. This is likely because of upper airway loading secondary to adenotonsillar hypertrophy and may contribute to the increased frequency of respiratory diseases in untreated children with OSAS.
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Registered trials
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