ArticleSmall (Weinheim an der Bergstrasse, Germany)2016
Probing Cell Deformability via Acoustically Actuated Bubbles.
Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
- Acoustic Bubble Sensing Techniques and Bioapplications.Biosensors · 2026Review
- Oscillating microbubble array-based metamaterials (OMAMs) for rapid isolation of high-purity exosomes.Science advances · 2025Article
- An Acoustofluidic Device for Sample Preparation and Detection of Small Extracellular Vesicles.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation.Nature communications · 2024Article
- An all-optical multidirectional mechano-sensor inspired by biologically mechano-sensitive hair sensilla.Nature communications · 2024Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Review of Bubble Applications in Microrobotics: Propulsion, Manipulation, and Assembly.Micromachines · 2022Review
- Current Development in Interdigital Transducer (IDT) Surface Acoustic Wave Devices for Live Cell In Vitro Studies: A Review.Micromachines · 2021Review
- Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review.Biomicrofluidics · 2021Review
- Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- On the shape-dependent propulsion of nano- and microparticles by traveling ultrasound waves.Nanoscale advances · 2020Article
- A Concentration Gradients Tunable Generator with Adjustable Position of the Acoustically Oscillating Bubbles.Micromachines · 2020Article
- On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis.Microsystems & nanoengineering · 2020Article
- Acoustofluidic methods in cell analysis.Trends in analytical chemistry : TRAC · 2019Article
- Acoustic Actuation of Integrin-Bound Microbubbles for Mechanical Phenotyping during Differentiation and Morphogenesis of Human Embryonic Stem Cells.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Acoustofluidic Measurements on Polymer-Coated Microbubbles: Primary and Secondary Bjerknes Forces.Micromachines · 2018Article
- A sharp-edge-based acoustofluidic chemical signal generator.Lab on a chip · 2018Article
- Microfluidic flow switchingRSC advances · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
An acoustically actuated, bubble-based technique is developed to investigate the deformability of cells suspended in microfluidic devices. A microsized bubble is generated by an optothermal effect near the targeted cells, which are suspended in a microfluidic chamber. Subsequently, acoustic actuation is employed to create localized acoustic streaming. In turn, the streaming flow results in hydrodynamic forces that deform the cells in situ. The deformability of the cells is indicative of their mechanical properties. The method in this study measures mechanical biomarkers from multiple cells in a single experiment, and it can be conveniently integrated with other bioanalysis and drug-screening platforms. Using this technique, the mean deformability of tens of HeLa, HEK, and HUVEC cells is measured to distinguish their mechanical properties. HeLa cells are deformed upon treatment with Cytochalasin. The technique also reveals the deformability of each subpopulation in a mixed, heterogeneous cell sample by the use of both fluorescent markers and mechanical biomarkers. The technique in this study, apart from being relevant to cell biology, will also enable biophysical cellular diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.