ArticleThe Journal of comparative neurology2016
Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal ganglia.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
- DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary innovations in the primate dopaminergic system.Current opinion in genetics & development · 2024Review
- Parkinson's Disease: Cells Succumbing to Lifelong Dopamine-Related Oxidative Stress and Other Bioenergetic Challenges.International journal of molecular sciences · 2024Review
- Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Striatonigrostriatal connectivity-based cross-species parcellation of human and macaque substantia nigra.Human brain mapping · 2023Article
- Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.NeuroImage · 2021Article
- The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates.Brain structure & function · 2021Article
- Genetic Mechanisms Underlying the Evolution of Connectivity in the Human Cortex.Frontiers in neural circuits · 2021Review
- Chinese and Western Musical Training Impacts the Circuit in Auditory and Reward Systems.Frontiers in neuroscience · 2021Article
- Decreased density of cholinergic interneurons in striatal territories in Williams syndrome.Brain structure & function · 2020Article
- Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.BMC evolutionary biology · 2019Article
- Dopamine modulates the reward experiences elicited by music.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Involvement of the Red Nucleus in the Compensation of Parkinsonism may Explain why Primates can develop Stable Parkinson's Disease.Scientific reports · 2019Article
- Species-Specific miRNAs in Human Brain Development and Disease.Frontiers in cellular neuroscience · 2019Article
- A neurochemical hypothesis for the origin of hominids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Is the Capacity for Vocal Learning in Vertebrates Rooted in Fish Schooling Behavior?Evolutionary biology · 2018Review
- HUMAN BRAIN EVOLUTION.Current opinion in behavioral sciences · 2017Article
- Review
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
The dopaminergic innervation of the striatum has been implicated in learning processes and in the development of human speech and language. Several lines of evidence suggest that evolutionary changes in dopaminergic afferents of the striatum may be associated with uniquely human cognitive and behavioral abilities, including the association of the human-specific sequence of the FOXP2 gene with decreased dopamine in the dorsomedial striatum of mice. To examine this possibility, we quantified the density of tyrosine hydroxylase-immunoreactive axons as a measure of dopaminergic innervation within five basal ganglia regions in humans, great apes, and New and Old World monkeys. Our results indicate that humans differ from nonhuman primate species in having a significant increase in dopaminergic innervation selectively localized to the medial caudate nucleus. This region of the striatum is highly interconnected, receiving afferents from multiple neocortical regions, and supports behavioral and cognitive flexibility. The medial caudate nucleus also shows hyperactivity in humans lacking a functional FOXP2 allele and exhibits altered dopamine concentrations in humanized Foxp2 mice. Additionally, striatal dopaminergic input was not altered in chimpanzees that used socially learned attention-getting sounds versus those that did not. This evidence indicates that the increase in dopamine innervation of the medial caudate nucleus in humans is a species-typical characteristic not associated with experience-dependent plasticity. The specificity of this increase may be related to the degree of convergence from cortical areas within this region of the striatum and may also be involved in human speech and language. J. Comp. Neurol. 524:2117-2129, 2016. © 2015 Wiley Periodicals, Inc.
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