ReviewModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2016
Practical issues in the diagnosis of serous carcinoma of the endometrium.
Review in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- A human-in-the-loop explanation framework for morphologically transparent AI predictions from whole-slide images.NPJ digital medicine · 2026Article
- Real-world benchmarking and validation of foundation model transformers for endometrial cancer subtyping from histopathology.NPJ precision oncology · 2026Article
- Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes in the Mouse Endometrium Recapitulates High-Risk Endometrial Carcinoma.Cancer communications (London, England) · 2026Article
- Aggressive Serous Carcinomas of the Female Reproductive Tract: Cancer-Prone Cell States and Genetic Drivers.Cancers · 2025Review
- Updated endometrial cancer FIGO staging: the role of MRI in determining newly included histopathological criteria.Abdominal radiology (New York) · 2024Article
- Mapping three-dimensional intratumor proteomic heterogeneity in uterine serous carcinoma by multiregion microsampling.Clinical proteomics · 2024Article
- Assessment of the localization of chondroitin sulfate in various types of endometrial carcinoma.PloS one · 2024Article
- Deep Learning-Based Classification of Uterine Cervical and Endometrial Cancer Subtypes from Whole-Slide Histopathology Images.Diagnostics (Basel, Switzerland) · 2022Article
- Risk Stratification of Stage I Grade 3 Endometrioid Endometrial Carcinoma in the Era of Molecular Classification.JCO precision oncology · 2022Article
- Article
- What Has Changed in the Management of Uterine Serous Carcinomas? Two Decades of Experience.Current oncology (Toronto, Ont.) · 2021Article
- Human epidermal growth factor receptor 2 targeted therapy in endometrial cancer: Clinical and pathological perspectives.World journal of clinical oncology · 2021Review
- Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs.The journal of obstetrics and gynaecology research · 2020Article
- Evaluation of HER2/neu Expression in High-Grade Endometrial Carcinoma and Its Clinicopathological Correlation.Iranian journal of pathology · 2019Article
- The evolution of endometrial carcinoma classification through application of immunohistochemistry and molecular diagnostics: past, present and future.Virchows Archiv : an international journal of pathology · 2018Review
- Are the uterine serous carcinomas underdiagnosed? Histomorphologic and immunohistochemical correlates and clinical follow up in high-grade endometrial carcinomas initially diagnosed as high-grade endometrioid carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Endometrial stromal sarcoma in combination with mixed type endometrial carcinomas: A case report and literature review.Medicine · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serous carcinoma (SC) represents ~10% of endometrial carcinomas, but is responsible for almost 40% of cancer deaths. This article reviews the main pathological features, differential diagnosis, and the usefulness of molecular pathology and immunohistochemistry in its diagnosis. Most helpful features for the diagnosis include: irregularly shaped and sized papillae, slit-like spaces, cell stratification and budding, highly atypical cells, architectural and cytological discordance in pseudoglandular tumors, as well as lack of endometrioid features. SC shows typically a predominant papillary growth, which is also found in some subtypes of endometrioid carcinoma of the endometrium (EEC). Distinction is easy when attention is paid to the presence of diffuse marked nuclear pleomorphism, but also to the complex papillary architecture. SC may also show a solid or pseudoglandular patterns, and in these cases differential diagnosis may be difficult with EEC grade 3. Moreover, a high proportion of SC may exhibit clear cells, and, thus, may be confused with clear cell carcinoma. Finally, it is sometimes difficult to distinguish mixed SC-EEC, from SC that combines papillary and pseudoglandular growths. Although there is not a single immunohistochemical marker for distinguishing SC from its mimickers, some antibodies are useful (p53, p16, IMP2, and IMP3), particularly when used in combination. Diagnosis of SC may be even more problematic in small biopsies; a diagnosis of high-grade endometrial carcinoma, SC component can not be excluded, is acceptable as a managerial approach, so it could be taken into account at the time of final surgery.
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