ArticleWorld journal of microbiology & biotechnology2016
Microbial production strategies and applications of lycopene and other terpenoids.
Article in World journal of microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Microbial synthesis and extraction of value-added metabolites by Rhodotorula toruloides from waste stream: a sustainable approach.Microbial cell factories · 2025Review
- Improvement of torularhodin production by Rhodotorula glutinis through the stimulation of physicochemical stress and application of the bioproduct as an additive in the food industry.Bioprocess and biosystems engineering · 2025Article
- Biosynthetic Pathway of psi, psi-Carotene fromFrontiers in microbiology · 2025Article
- Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2024Article
- Iterative gene integration mediated by 26S rDNA and non-homologous end joining for the efficient production of lycopene in Yarrowia lipolytica.Bioresources and bioprocessing · 2023Article
- Enhanced β-carotene production in Yarrowia lipolytica through the metabolic and fermentation engineering.Journal of industrial microbiology & biotechnology · 2023Article
- Engineering a mevalonate pathway inFrontiers in microbiology · 2022Article
- Carotenoids produced by the deep-sea bacterium Erythrobacter citreus LAMA 915: detection and proposal of their biosynthetic pathway.Folia microbiologica · 2021Article
- Transcriptome Analysis Reveals a Promotion of Carotenoid Production by Copper Ions in RecombinantMicroorganisms · 2021Article
- Systematical Engineering of Synthetic Yeast for Enhanced Production of Lycopene.Bioengineering (Basel, Switzerland) · 2021Article
- Enhanced Lycopene Production by UV-C Irradiation in Radiation-ResistantJournal of microbiology and biotechnology · 2020Article
- Metabolic EngineeringMolecules (Basel, Switzerland) · 2020Review
- Design and tailoring of an artificial DNA scaffolding system for efficient lycopene synthesis using zinc-finger-guided assembly.Journal of industrial microbiology & biotechnology · 2020Article
- Identifying and engineering the ideal microbial terpenoid production host.Applied microbiology and biotechnology · 2019Review
- Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications.Molecules (Basel, Switzerland) · 2019Review
- An approach to enhanced stability: Formulation and characterization ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Extending our tools and resources in the non-conventional industrial yeastMetabolomics : Official journal of the Metabolomic Society · 2018Article
- Metabolic engineering for the microbial production of isoprenoids: Carotenoids and isoprenoid-based biofuels.Synthetic and systems biotechnology · 2017Review
- Enhanced pinocembrin production in Escherichia coli by regulating cinnamic acid metabolism.Scientific reports · 2016Article
- Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering.Microbial cell factories · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terpenoids are a large class of compounds that have far-reaching applications and economic value, particularly those most commonly found in plants; however, the extraction and synthesis of these compounds is often expensive and technically challenging. Recent advances in microbial metabolic engineering comprise a breakthrough that may enable the efficient, cost-effective production of these limited natural resources. Via the engineering of safe, industrial microorganisms that encode product-specific enzymes, and even entire metabolic pathways of interest, microbial-derived semisynthetic terpenoids may soon replace plant-derived terpenoids as the primary source of these valuable compounds. Indeed, the recent metabolic engineering of an Escherichia coli strain that produces the precursor to lycopene, a commercially and medically important compound, with higher yields than those in tomato plants serves as a successful example. Here, we review the recent developments in the metabolic engineering of microbes for the production of certain terpenoid compounds, particularly lycopene, which has been increasingly used in pharmaceuticals, nutritional supplements, and cosmetics. Furthermore, we summarize the metabolic engineering strategies used to achieve successful microbial production of some similar compounds. Based on this overview, there is a reason to believe that metabolic engineering comprises an optimal approach for increasing the production of lycopene and other terpenoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.