Evidence map›Paper›PMID 26715108›Full record

SynthesisClinical drug investigation2016

Prophylactic Administration of Corticosteroids for Preventing Postoperative Complications Related to Tracheal Intubation: A Systematic Review and Meta-Analysis of 18 Randomized Controlled Trials.

Wenyu Zhang, Guoqing Zhao, Longyun Li, Pengcheng Zhao

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical drug investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Prevalence and risk factors of postoperative laryngeal edema in patients undergoing neck dissection.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wenyu ZhangDepartment of Anesthesiology, The China-Japan Union Hospital, Jilin University, No. 126, Xiantai Street, 130033, Changchun, Jilin, China.
Guoqing ZhaoDepartment of Anesthesiology, The China-Japan Union Hospital, Jilin University, No. 126, Xiantai Street, 130033, Changchun, Jilin, China.
Longyun LiDepartment of Anesthesiology, The China-Japan Union Hospital, Jilin University, No. 126, Xiantai Street, 130033, Changchun, Jilin, China.
Pengcheng ZhaoDepartment of Anesthesiology, The China-Japan Union Hospital, Jilin University, No. 126, Xiantai Street, 130033, Changchun, Jilin, China. zwyxcy000@163.com.
Union Hospital · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSore throat, cough, and hoarseness are the common and severe complications after general anesthesia with tracheal intubation. The efficacy of prophylactic administration of corticosteroids in reducing the incidence of postoperative complications is controversial. Thus, we conducted a meta-analysis to assess the effects of corticosteroids in the prevention of postoperative complications.

methodsA comprehensive literature search of Pubmed, Embase, and Web of Science was conducted to identify relative trials. Eligible studies were randomized controlled trials (RCTs) that assessed the effect of corticosteroids for preventing postoperative complications. The outcomes included the prevalence of postoperative sore throat, cough, hoarseness, laryngeal edema, and reintubation. A random-effects or fixed-effects model was used to pool the estimates, according to the heterogeneity among the included studies.

resultsEighteen RCTs with a total of 2685 patients were included in this meta-analysis. Pooled estimates showed that corticosteroids significantly reduced the incidence of postoperative sore throat, hoarseness, and cough. Moreover, corticosteroids had a positive effect on the incidence of laryngeal edema and reintubation. Subgroup analysis showed that corticosteroids significantly decreased the incidence of severe sore throat and hoarseness, but not cough.

conclusionEvidence from this meta-analysis of 18 RCTs indicated that prophylactic administration of corticosteroids is not only effective in reducing the incidence and severity of postoperative sore throat and hoarseness, but also the incidence of laryngeal edema and reintubation.

Indexed as

AdolescentAdrenal Cortex HormonesAdultAgedAged, 80 and overAnti-Inflammatory AgentsFemaleHumansIntubation, IntratrachealMaleMiddle AgedPostoperative ComplicationsRandomized Controlled Trials as TopicYoung AdultAdrenal Cortex HormonesAnti-Inflammatory Agents

Identifiers

PMID26715108
OpenAlexW2221678550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.