ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2016
Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Cadmium exposure, epigenetic modifications, and serum cystatin C: insights into mediated pathways and mortality risks in U.S. adults.Clinical epigenetics · 2025Article
- Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHANES 2015-2018.BMC public health · 2025Article
- A population-based urinary and plasma metabolomics study of environmental exposure to cadmium.Environmental health and preventive medicine · 2024Article
- Nephrotoxic Metal Mixtures and Preadolescent Kidney Function.Children (Basel, Switzerland) · 2021Article
- Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population.Environmental science and pollution research international · 2021Article
- Evaluation of the effect of serum cystatin-C and ACE I/D and ACE G2350A polymorphisms on kidney function among hypertensive sewage workers.Environmental science and pollution research international · 2021Article
- Evaluation of Fetal and Maternal Vancomycin-Induced Kidney Injury during Pregnancy in a Rat Model.Antimicrobial agents and chemotherapy · 2019Article
- Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.Physiological reports · 2019Article
- Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits.Environmental science and pollution research international · 2019Article
- Cadmium Exposure Disrupts Periodontal Bone in Experimental Animals: Implications for Periodontal Disease in Humans.Toxics · 2018Article
- Cadmium Nephrotoxicity Is Associated with Altered MicroRNA Expression in the Rat Renal Cortex.Toxics · 2018Article
- Dietary Cadmium Intake and Its Effects on Kidneys.Toxics · 2018Review
- The impact of repeated cycles of radioligand therapy using [European journal of nuclear medicine and molecular imaging · 2017Article
- Chronic Kidney Disease and Exposure to Nephrotoxic Metals.International journal of molecular sciences · 2017Review
- Effects of sub-chronic Cd exposure on levels of copper, selenium, zinc, iron and other essential metals in rat renal cortex.Toxicology reports · 2016Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Cadmium (Cd) is a nephrotoxic environmental pollutant that causes insidious injury to the proximal tubule that results in severe polyuria and proteinuria. Cystatin C is a low molecular weight protein that is being evaluated as a serum and urinary biomarker for various types of ischemic and nephrotoxic renal injury. The objective of the present study was to determine if cystatin C might be a useful early biomarker of Cd nephrotoxicity. Male Sprague-Dawley rats were given daily injections of Cd for up to 12 weeks. At 3, 6, 9 and 12 weeks, urine samples were analyzed for cystatin C, protein, creatinine, β2 microglobulin and kidney injury molecule-1. The results showed that Cd caused a significant increase in the urinary excretion of cystatin C that occurred 3-4 weeks before the onset of polyuria and proteinuria. Serum levels of cystatin C were not altered by Cd. Immunolabeling studies showed that Cd caused the relocalization of cystatin C from the cytoplasm to the apical surface of the epithelial cells of the proximal tubule. The Cd-induced changes in cystatin C labelling paralleled those of the brush border transport protein, megalin, which has been implicated as a mediator of cystatin C uptake in the proximal tubule. These results indicate that Cd increases the urinary excretion of cystatin C, and they suggest that this effect may involve disruption of megalin-mediated uptake of cystatin C by epithelial cells of the proximal tubule.
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