Trial reportRespiratory research2015
Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study.
Trial report in Respiratory research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effects of Beetroot Juice on Physical Performance in Professional Athletes and Healthy Individuals: An Umbrella Review.Nutrients · 2025Pooled it
- Examining the Role of Exercise Training in Enhancing Life for Adult Congenital Heart Disease: Systematic Review.Arquivos brasileiros de cardiologia · 2024Pooled it
- Lung function parameters improve prediction of VO2peak in an elderly population: The Generation 100 study.PloS one · 2017Trial
- Lung function and ventilatory response during high-intensity treadmill walking in adults with cerebral palsy: a cross-sectional study.Journal of rehabilitation medicine · 2026Article
- Cardiorespiratory fitness in working adults undergoing rehabilitation: the role of lifestyle and body composition- a cross-sectional study.Frontiers in physiology · 2026Article
- Aerobic capacity and cardiopulmonary variables are not different between premenopausal, late premenopausal, perimenopausal, and postmenopausal women.Physiological reports · 2025Article
- Vitamin D and its relationship to performance and health during a competitive period in elite women's basketball and volleyball players.Physiological reports · 2025Article
- Longitudinal Changes in Peak Expiratory Flow Predict Risk for Incident Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Respiratory Dysfunction in Alzheimer's Disease-Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions.International journal of molecular sciences · 2024Review
- Peak Expiratory Flow Predicts Incident Dementia in a Representative Sample of U.S. Older Adults: The National Health and Aging Trends Study (NHATS).The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- The global lung function initiative 2021 (GLI-2021) norms provide mixed results for static lung volumes (SLVs) in Algerian adults.The Libyan journal of medicine · 2022Article
- The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community.The European respiratory journal · 2022Article
- Does Regular Physical Activity Mitigate the Age-Associated Decline in Pulmonary Function?Sports medicine (Auckland, N.Z.) · 2022Article
- Addressing Race in Pulmonary Function Testing by Aligning Intent and Evidence With Practice and Perception.Chest · 2022Review
- Article
- Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study.Journal of Alzheimer's disease : JAD · 2021Article
- Association of preoperative spirometry with cardiopulmonary fitness and postoperative outcomes in surgical patients:EClinicalMedicine · 2020Article
- Lifelong Endurance Exercise as a Countermeasure Against Age-RelatedSports medicine (Auckland, N.Z.) · 2020Review
- The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough reduced function of the respiratory system limits peak oxygen uptake in diseases affecting the lungs or airways, the healthy respiratory system is thought to have a spare capacity for oxygen transport and uptake, and is not considered a limiting factor for peak oxygen uptake in healthy people. However, lung function declines with age and could theoretically limit peak oxygen uptake in elderly. We examined the association between peak oxygen uptake and lung function indices in an elderly population with the hypothesis that lung function indices would be associated with VO2peak up to a threshold value situated above the lower limits of normal lung function for our population.
methodsSpirometry, gas diffusion tests and incremental work tests were performed in 1443 subjects (714 women) aged 69-77 years. Association between lung function indices and peak oxygen uptake was studied with hockey-stick regression.
resultsForced expiratory volume in 1 s (FEV1) had a positive association with peak oxygen uptake up to, but not above, a threshold value of 2.86 l for men, and 2.13 l for women (lower limit of normal 2.73 and 1.77 l respectively). A corresponding threshold was found for diffusing capacity of the lung for carbon monoxide (DLCO) for men at 9.18 mmol/min/kPa (lower limit of normal 6.84 mmol/min/kPa). DLCO for women and DLCO divided by alveolar volume (DLCO/VA) for both sexes had a significant linear relationship to VO2peak (p < 0.05), but no significant threshold value was found in these associations.
conclusionsThreshold values for FEV1 for both sexes and DLCO for men were identified. These lung function indices had a positive association with VO2peak up to these threshold values, but not above. The identified threshold values were above lower limits of normal for FEV1 and DLCO.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.