ArticleBMC genomics2015
Structure, evolution and functional inference on the Mildew Locus O (MLO) gene family in three cultivated Cucurbitaceae spp.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed.
- Visual marker-assisted gene editing ofaBIOTECH · 2026Article
- Identification and Expression Analysis of theLife (Basel, Switzerland) · 2026Article
- Turning Susceptibility into Strength: A New Era of Durable Resistance in Plants Through Genome Editing.Plants (Basel, Switzerland) · 2025Review
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- Hazelnut allergome overview and Cor a gRNAs identification.BMC plant biology · 2025Article
- Identification of Genomic Regions Associated with Powdery Mildew Resistance in Watermelon through Genome-Wide Association Study.Plants (Basel, Switzerland) · 2024Article
- The First Genome-Wide Mildew Locus O Genes Characterization in theInternational journal of molecular sciences · 2023Article
- Functional and evolutionary study of MLO gene family in the regulation of Sclerotinia stem rot resistance in Brassica napus L.Biotechnology for biofuels and bioproducts · 2023Article
- Article
- Genome-wide identification, evolution, and expression analysis ofFrontiers in plant science · 2023Article
- Advanced Genetic Studies on Powdery Mildew Resistance in TGR-1551.International journal of molecular sciences · 2022Article
- Transcriptomic and genomic analysis provides new insights in molecular and genetic processes involved in zucchini ZYMV tolerance.BMC genomics · 2022Article
- CmPMRl and CmPMrs are responsible for resistance to powdery mildew caused by Podosphaera xanthii race 1 in Melon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Comparative transcriptome analysis of melon (Cucumis melo L.) reveals candidate genes and pathways involved in powdery mildew resistance.Scientific reports · 2022Article
- Article
- Genome-Wide Characterization of theFrontiers in plant science · 2021Article
- Article
- Evolutionary conservation of MLO gene promoter signatures.BMC plant biology · 2019Article
- Functional characterization of the powdery mildew susceptibility gene SmMLO1 in eggplant (Solanum melongena L.).Transgenic research · 2017Article
- Functional characterization of cucumber (Cucumis sativus L.) Clade V MLO genes.BMC plant biology · 2017Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe powdery mildew disease affects thousands of plant species and arguably represents the major fungal threat for many Cucurbitaceae crops, including melon (Cucumis melo L.), watermelon (Citrullus lanatus L.) and zucchini (Cucurbita pepo L.). Several studies revealed that specific members of the Mildew Locus O (MLO) gene family act as powdery mildew susceptibility factors. Indeed, their inactivation, as the result of gene knock-out or knock-down, is associated with a peculiar form of resistance, referred to as mlo resistance.
resultsWe exploited recently available genomic information to provide a comprehensive overview of the MLO gene family in Cucurbitaceae. We report the identification of 16 MLO homologs in C. melo, 14 in C. lanatus and 18 in C. pepo genomes. Bioinformatic treatment of data allowed phylogenetic inference and the prediction of several ortholog pairs and groups. Comparison with functionally characterized MLO genes and, in C. lanatus, gene expression analysis, resulted in the detection of candidate powdery mildew susceptibility factors. We identified a series of conserved amino acid residues and motifs that are likely to play a major role for the function of MLO proteins. Finally, we performed a codon-based evolutionary analysis indicating a general high level of purifying selection in the three Cucurbitaceae MLO gene families, and the occurrence of regions under diversifying selection in candidate susceptibility factors.
conclusionsResults of this study may help to address further biological questions concerning the evolution and function of MLO genes. Moreover, data reported here could be conveniently used by breeding research, aiming to select powdery mildew resistant cultivars in Cucurbitaceae.
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