ReviewJournal of muscle research and cell motility2015
From pluripotency to myogenesis: a multistep process in the dish.
Review in Journal of muscle research and cell motility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Mesoderm and myogenesis-related lncRNAs as Potential Markers of Myogenic Differentiation of Control and miR145 or miR181 Stimulated Mouse Pluripotent Stem Cells.Stem cell reviews and reports · 2026Article
- Addressing hurdles in cultured meat by exploring reduced myogenesis after bovine myoblast expansion.Communications biology · 2025Article
- Can cell-cultured meat from stem cells pave the way for sustainable alternative protein?Current research in food science · 2025Article
- Future protein alternative: recent progress and challenges in cellular agriculture.Food science and biotechnology · 2025Review
- Actin-organizing protein palladin modulates C2C12 cell fate determination.Biochemistry and biophysics reports · 2024Article
- Influence ofInternational journal of molecular sciences · 2023Review
- TheAnimals : an open access journal from MDPI · 2022Article
- Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection.Cells · 2022Article
- Intestinal organoids: roadmap to the clinic.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.Stem cell research & therapy · 2020Article
- Alterations in pectoralis muscle cell characteristics after radiation of the human breast in situ.Journal of radiation research · 2019Article
- Interleukin 4 Moderately Affects Competence of Pluripotent Stem Cells for Myogenic Conversion.International journal of molecular sciences · 2019Article
- Adipose Tissue-Derived Stromal Cells in Matrigel Impacts the Regeneration of Severely Damaged Skeletal Muscles.International journal of molecular sciences · 2019Article
- Study on the transcriptional regulatory mechanism of the MyoD1 gene in Guanling bovine.RSC advances · 2018Article
- Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis.Cell adhesion & migration · 2017Article
- Embryonic-only arsenic exposure in killifish (Fundulus heteroclitus) reduces growth and alters muscle IGF levels one year later.Aquatic toxicology (Amsterdam, Netherlands) · 2017Article
- A process engineering approach to increase organoid yield.Development (Cambridge, England) · 2017Article
- Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7.Cell cycle (Georgetown, Tex.) · 2016Article
- Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.Nature protocols · 2016Article
- Insight into muscle physiology through understanding mechanisms of muscle pathology.Journal of muscle research and cell motility · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotent stem cells (PSCs), such as embryonic stem cells or induced pluripotent stem cells are a promising source of cells for regenerative medicine as they can differentiate into all cell types building a mammalian body. However, protocols leading to efficient and safe in vitro generation of desired cell types must be perfected before PSCs can be used in cell therapies or tissue engineering. In vivo, i.e. in developing mouse embryo or teratoma, PSCs can differentiate into skeletal muscle, but in vitro their spontaneous differentiation into myogenic cells is inefficient. Numerous attempts have been undertaken to enhance this process. Many of them involved mimicking the interactions occurring during embryonic myogenesis. The key regulators of embryonic myogenesis, such as Wnts proteins, fibroblast growth factor 2, and retinoic acid, have been tested to improve the frequency of in vitro myogenic differentiation of PSCs. This review summarizes the current state of the art, comparing spontaneous and directed myogenic differentiation of PSCs as well as the protocols developed this far to facilitate this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.