Evidence map›Paper›PMID 26714889›Full record

ArticleBMC infectious diseases2015

Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men.

Yu Liu, Yuhua Ruan, Sten H Vermund, Chandra Y Osborn, Pingsheng Wu, Yujiang Jia, Yiming Shao, Han-Zhu Qian

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yu LiuVanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. yu.liu@vanderbilt.edu.
Yuhua RuanState Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China. ruanyuhua92@163.com.
Sten H VermundVanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. sten.vermund@vanderbilt.edu.
Chandra Y OsbornDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. chandra.osborn@vanderbilt.edu.
Pingsheng WuDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. pingsheng.wu@vanderbilt.edu.
Yujiang JiaVanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. jiay946@163.com.
Yiming ShaoState Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China. yshao08@gmail.com.
Han-Zhu QianVanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. han-zhu.qian@vanderbilt.edu.
Vanderbilt University · USChinese Center For Disease Control and Prevention · CNVanderbilt Health · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)KL2TR000446 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$2.8M
Multi-component HIV Intervention Packages for Chinese MSMR01AI094562 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI QIAN, HAN-ZHU, VERMUND, STEN H. · 2011 to 2014
$2.5M
FUNCTION OF AND SIGNALING BY THE B CELL PROTEINF32AI009462 · NIAID · STANFORD UNIVERSITY · PI PAN, CHIN · 1996 to 1996
–
NCATS NIH HHS KL2 TR000446NCATS NIH HHS KL2TR000446NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NIAID NIH HHS F32 AI009462NIAID NIH HHS R01 AI094562NIAID NIH HHS R01AI094562
6 · The paper itself

Abstract

backgroundEarly antiretroviral therapy (ART) initiation is crucial to achieve HIV viral suppression and reduce transmission. HIV-infected Chinese men who have sex with men (MSM) were less likely to initiate ART than other HIV-infected individuals. We assessed predictors of ART initiation among Chinese MSM.

methodsIn 2010-2011, a cross-sectional study was conducted among MSM in Beijing, China. We examined ART initiation within the subgroup who were diagnosed with HIV infection prior to participation in the survey. Logistic regression models were fitted to evaluate socio-demographic and behavioral factors associated with ART initiation. The eligibility criterion in the 2010/2011 national HIV treatment guidelines was CD4 cell count <350 cells/μL or World Health Organization (WHO) clinical stage III/IV.

resultsOf 238 eligible HIV-infected participants, the median duration of HIV infection was 15 months (range: 31 days-12 years); 62 (26.1 %) had initiated ART. Among 103 men with CD4 counts <350 cells/μL, 38 (36.9 %) initiated ART. Being married to a woman (adjusted odd ratios [aOR]: 2.50; 95 % confidence interval [CI]: 1.07-5.87), longer duration of HIV infection (aOR: 10.71; 95 % CI: 3.66-31.32), and syphilis co-infection (aOR: 2.58; 95 % CI: 1.04-6.37) were associated with a higher likelihood of ART initiation. Of 135 men with CD4 count ≥350 cells/μL, 24 (18 %) initiated ART. Being married to a woman (aOR: 4.21; 95 % CI: 1.60-11.06), longer duration of HIV infection (aOR: 22.4; 95 % CI: 2.79-180), older age (aOR: 1.26; 95 % CI: 1.1-1.44), Beijing Hukou (aOR: 4.93; 95 % CI: 1.25-19.33), presence of AIDS-like clinical symptoms (aOR: 3.97; 95 % CI: 1.32-14.0), and history of sexually transmitted infections (aOR: 4.93; 95 % CI: 1.25-19.43) were associated with ART initiation. Compared with men who did not initiated ART, those with ART were more likely to receive counseling on benefits of ART (96.8 % vs. 66.4 %, P = 0 < 0.01), HIV stigma coping strategy (75.8 % vs. 65.9 %, P = 0.04), mental health (66.1 % vs. 52.9 %, P = 0.02), and substance use (46.7 % vs. 36.6 %, P = 0.04).

conclusionsWe documented low rates of ART initiation among Chinese MSM. Policy changes for expanding ART eligibility and interventions to improve the continuum of HIV care are in progress in China. Impact evaluations can help assess continuing barriers to ART initiation among MSM.

Indexed as

Homosexuality, MaleAdultAntiretroviral Therapy, Highly ActiveBeijingCD4 Lymphocyte CountCoinfectionCounselingCross-Sectional StudiesFemaleHIV InfectionsHumansLogistic ModelsMaleOdds RatioSexually Transmitted DiseasesSocioeconomic Factors

Identifiers

PMID26714889
PMCPMC4696158
OpenAlexW2199709515

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.